In male mice fed a high-fat diet from 6 to 12 months of age, oral bacterial supplementation reduced weight gain and memory impairments.In male mice fed a high-fat diet from 6 to 12 months of age, oral bacterial supplementation reduced weight gain and memory impairments.
Experiments in male wild-type C57BL/6J mice, 6 consecutive months, against the HFD groupGut and microbiome
Limit: Serum metabolomics was not measured in the high-fat diet or Akk supplementation groups
In 40 postmenopausal women, blood and muscle measurements suggested distinct changes rather than a uniform shift across the lysine breakdown pathway.In 40 postmenopausal women, blood and muscle measurements suggested distinct changes rather than a uniform shift across the lysine breakdown pathway.
Mendelian randomisation in people represented in genome-wide association studiesMechanisms
Limit: The multi-omics validation cohort included only 40 postmenopausal women
An 8-week wheel-running experiment in mice examined 22 tissues and plasma, finding the largest gene-activity changes in skeletal muscle.An 8-week wheel-running experiment in mice examined 22 tissues and plasma, finding the largest gene-activity changes in skeletal muscle.
In an animal experiment, 7-ketodeoxycholic acid also restored muscle function and enhanced exercise capacity in mice with type 2 diabetes.In an animal experiment, 7-ketodeoxycholic acid also restored muscle function and enhanced exercise capacity in mice with type 2 diabetes.
An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the…An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the lab.
Experiments in primary human fibroblastsInterventions
Limit: Senescence features are a proxy for cellular ageing, not a direct measure of it
A cohort study of 10,115 Finnish men linked 45 blood metabolites to later heart failure, including 33 newly identified associations.A cohort study of 10,115 Finnish men linked 45 blood metabolites to later heart failure, including 33 newly identified associations.
Cohort study of 10,115 Finnish men, 14.2 yearsHeart failure
Limit: Only Finnish men were included, limiting applicability to women and other populations
After six hours at 1.0 parts per million, mice had temporary breathing problems and lung tissue damage that remained seven days after exposure.After six hours at 1.0 parts per million, mice had temporary breathing problems and lung tissue damage that remained seven days after exposure.
Experiments in aged male C57BL/6J mice, 7 daysLung
Limit: Assessment at 7 days leaves longer-term lung damage uncertain
An observational study spanning 18,476 people in China linked an aging measure developed in a healthy group to chronic disease and death risk.An observational study spanning 18,476 people in China linked an aging measure developed in a healthy group to chronic disease and death risk.
Cohort study of healthy-cohort participants in China, 2019 to 2025Biomarkers
Limit: The abstract omits risk-increase sizes, leaving the strength of the associations unclear