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Selection for early reproduction

Intervention

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Bristol-Myers Squibb and others
  • Model organisms2

Outcomes

3

Cellular senescence

upin flies1

1 study

  1. Selection for early reproduction increases cellular senescence in flies.

    “selection for early reproduction has led to an accelerated aging phenotype relative to their controls”

    Model organismsexperimental evolution

    Selection for Early Reproduction Leads to Accelerated Aging and Extensive Metabolic Remodeling in Drosophila melanogaster

    Genome biology and evolution30 Apr 2025

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Metabolome

upin flies1

1 study

  1. Selection for early reproduction induces metabolome in flies.

    “selection for early reproduction resulted in highly repeatable alterations to the metabolome”

    Model organismsadult lifespan

    Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster

    bioRxiv : the preprint server for biology15 Jul 2024Preprint

More on Metabolome

Rate of aging

upin flies1

1 study

  1. Selection for early reproduction increases rate of aging in flies.

    “selection for early reproduction has led to an accelerated aging phenotype relative to their controls.”

    Model organismspopulations selected for early reproduction relative to controls

    Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster

    bioRxiv : the preprint server for biology15 Jul 2024Preprint

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