Incident cardiovascular disease
Disease2 papers5 findings
- Humans2
Upstream
1Thyroid peroxidase antibodies
no changein humans1
1 study
Thyroid peroxidase antibodies
no changein humans1
Thyroid peroxidase antibodies have no effect on incident cardiovascular disease in humans (Adjusted HR per 1-SD increase: 1.04, 95% CI 0.95–1.13).
HumansWithout baseline cardiovascular disease; adjusted analysis per 1-SD increase14.8 ± 3.3 years after landmark56.5% femalesn = 4,825
Thyroid antibodies linked to heart risk in younger adults · Journal of translational autoimmunity · 22 Sep 2026
Associations
4Three-domain life-course burden
upin humans1
1 study
Three-domain life-course burden
upin humans1
Three-domain life-course burden is associated with incident cardiovascular disease in humans.
HumansSecondary analysis; non-uniform categorical patterns
Cohort-specific childhood adversity measures and incident cardiovascular disease across four ageing cohorts: analyses of childhood hunger, later-life psychosocial indicators, and life-course burden · BMC public health · 5 Oct 2026
Childhood hunger
upin humans1Low certainty
1 study
Childhood hunger
upin humans1Low certainty
Childhood hunger is associated with incident cardiovascular disease in humans (Hartung–Knapp CI 0.95–1.41; positive estimates but interval included 1).
HumansCHARLS and SHARE; two-cohort pooled estimate with Hartung–Knapp confidence interval
Cohort-specific childhood adversity measures and incident cardiovascular disease across four ageing cohorts: analyses of childhood hunger, later-life psychosocial indicators, and life-course burden · BMC public health · 5 Oct 2026
Observed-domain childhood adversity index
upin humans1HR 1.07
1 study
Observed-domain childhood adversity index
upin humans1HR 1.07
Observed-domain childhood adversity index is associated with incident cardiovascular disease in humans (HR 1.07, 95% CI 1.03–1.10 per additional observed adverse domain).
HumansComplete-case risk sets; descriptive pooling across non-equivalent cohort-specific measures, adjusted for age, sex, birth cohort, smoking, alcohol, and BMIper additional observed adverse domain
Cohort-specific childhood adversity measures and incident cardiovascular disease across four ageing cohorts: analyses of childhood hunger, later-life psychosocial indicators, and life-course burden · BMC public health · 5 Oct 2026
Thyroid peroxidase antibodies
upin humans1HR 1.35
1 study
Thyroid peroxidase antibodies
upin humans1HR 1.35
Thyroid peroxidase antibodies are associated with incident cardiovascular disease in humans (Adjusted HR 1.35, 95% CI 1.10–1.66).
HumansExploratory age-stratified adjusted analysis; without baseline cardiovascular disease
Thyroid antibodies linked to heart risk in younger adults · Journal of translational autoimmunity · 22 Sep 2026
Latest
8Thyroid antibodies linked to heart risk in younger adults
Across 4,825 adults followed for 14.8 years on average, thyroid antibodies were linked to cardiovascular risk in participants under 40 but not in…Across 4,825 adults followed for 14.8 years on average, thyroid antibodies were linked to cardiovascular risk in participants under 40 but not in those aged 40 and older.
High HbA1c-to-HDL-C ratio linked to CVD risk in older adults
Older adults in the highest ratio quartile had a higher risk of incident cardiovascular disease than those in the lowest (HR = 2.111) over five years.Older adults in the highest ratio quartile had a higher risk of incident cardiovascular disease than those in the lowest (HR = 2.111) over five years.
Retinal asymmetry between eyes is linked to cardiovascular risk
Across 46,836 adults, each standard deviation increase in retinal nerve fiber layer asymmetry was linked to hazard ratios from ~1.07 for atrial…Across 46,836 adults, each standard deviation increase in retinal nerve fiber layer asymmetry was linked to hazard ratios from ~1.07 for atrial fibrillation to 1.15 for heart failure.
Retinal imaging model predicts age and reveals sex differences in human aging
The retinal age gap correlates with mortality, disease risks, and sex-specific genetic pathways in more than 71,000 UK Biobank participants.The retinal age gap correlates with mortality, disease risks, and sex-specific genetic pathways in more than 71,000 UK Biobank participants.