Poor sleep

6 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

5 independent labs in 1 country

Human trial1
Humans4

Outcomes

Cognitive functioning

downin humans1

1 study

Poor sleep impairs cognitive functioning in humans.
“Sleep disturbances are strongly associated with poorer cognitive functioning across multiple domains, with the greatest impact observed among older adults.”
Humans
Does poor sleep affect cognition differently across ages? Insights from a national cohort
Sleep medicine2 Mar 2026

Oculometric task performance

downin humans1

1 study

Poor sleep impairs oculometric task performance in humans (mean score = -.051 (s =.52)).
“Poor sleep the night before (n = 7 instances) also may impair performance (mean score = -.051 (s =.52).”
Humans6 monthsfemales
USE OF OCULOMETRICS AS AN AT HOME BRAIN HEALTH MONITORING TOOL: A CASE STUDY
GSA 2024 abstract31 Dec 2024

Frailty

upin humans1

1 study

Poor sleep increases frailty in humans (p=0.0248).
“FRAIL (p=0.0248) and STEADI scores (p=0.0338) significantly increased with low sleep duration.”
Humanslow sleep (< 7 hours; n=83) versus healthy sleep (7-8 hours; n=72)
INADEQUATE SLEEP ASSOCIATED WITH FRAILTY DEVELOPMENT AND FALL RISK IN LOW-INCOME OLDER ADULTS
GSA 2024 abstract31 Dec 2024

Associations

Motoric cognitive risk syndrome

upin humans1HR 1.3

1 study

Poor sleep raises the risk of motoric cognitive risk syndrome in humans (HR 1.30, 95% CI: 1.00–1.69).
“frequent poor sleepers had higher odds of developing MCR compared to those with rare poor sleep (HR = 1.30, 95% CI: 1.00–1.69).”
Humanscompared to rare poor sleep50% femalesn = 4,359
Longitudinal Association of Sleep Quality and Duration With Motoric Cognitive Risk Syndrome in Chinese Older Adults
GSA 2025 abstract31 Dec 2025