Systolic blood pressure

1. Exercise decreases systolic blood pressure in humans (-4.6 mmHg (95% CI: 2.36-6.84)).

   Human trial12 weeks

   Workplace-embedded exercise-snack to interrupt sedentary work: A 12-week randomized trial on blood pressure and perceived stress with implementation implications · Acta psychologica · 29 Sep 2026

2. Exercise decreases systolic blood pressure in humans (adjusted mean difference -7.2 mmHg, 95% CI -10.5 to -3.9).

   Human trial12 weeksfemalesn = 46

   Baguazhang lowers systolic blood pressure in postmenopausal women · Frontiers in physiology · 18 Sep 2026

Exercise →

1. Low-carbohydrate high-fat diet decreases systolic blood pressure in humans.

   “SBP in the LCHF Opti group”

   Human trial4 weeks

   Optimized Nutri-Dense meals versus a low-carbohydrate high-fat diet: an exploratory randomized controlled trial · Scientific reports · 3 Oct 2026

Low-carbohydrate high-fat diet →

1. SGLT2 inhibitors decrease systolic blood pressure in humans (MD = -2.98 mm Hg, 95% CI: -3.44 to -2.52).

   Reviewin patients with diabetic CKD

   Renoprotective effects and safety of sodium-glucose cotransporter 2 inhibitors in diabetic chronic kidney disease: A systematic review and meta-analysis · Medicine · 2 Oct 2026

SGLT2 inhibitors →

1. Digital food-as-medicine decreases systolic blood pressure in humans (−3.33 mmHg (95% CI −6.40 to −0.26)).

   HumansStage-1 baseline blood pressure6 monthsn = 34

   Blood Pressure Reduction in Multiomic Digital Food-as-Medicine: a single-arm cohort study with a regression-to-the-mean-adjusted estimand · medRxiv · 1 Oct 2026 · Preprint

Digital food-as-medicine →

1. Isometric exercise training decreases systolic blood pressure in humans (-9.45±6.69 mm Hg).

   Human trialcompared with control4 weeks

   Isometric exercise training and blood pressure control: exploring the dose-response to training frequency in a randomised controlled trial · BMJ open sport & exercise medicine · 29 Sep 2026

Isometric exercise training →

1. Systolic blood pressure raises the risk of stroke in humans (SHR 1.37, 95% CI 1.26-1.48).

   Humansper 1 SD

   Triangulating population, individual, and genetic evidence for priority setting in structurally heterogeneous blocs: metabolic risk factors for stroke in the Shanghai Cooperation Organisation · medRxiv · 1 Oct 2026 · Preprint

Stroke →

1. Systolic blood pressure raises the risk of renal insufficiency in humans (AOR: 1.052; 95% CI: 1.005-1.101).

   Humansolder adults living with HIV on antiretroviral therapyn = 318

   Prevalence and incidence of non-communicable diseases among older adults living with HIV on antiretroviral therapy in Northern Haiti: A retrospective cohort study · PLOS global public health · 1 Oct 2026

Renal insufficiency →

1. Systolic blood pressure is associated with cognitive function in humans (peak at 120.1 mmHg).

   Humansoverall cohort

   Age and frailty shift optimal blood pressure for cognitive aging · Journal of Alzheimer's disease : JAD · 29 Sep 2026

1. Systolic blood pressure is associated with subclinical myocardial injury in humans (adjusted odds ratio: 1.13 per mmHg increase, 95% confidence interval: 1.05-1.24).

   “higher systolic blood pressure was independently associated with biochemical evidence suggestive of subclinical myocardial injury after adjusting for demographic, metabolic, and cardiovascular risk factors”

   Humansin adults with prediabetes

   Evaluation of biochemical evidence suggestive of subclinical myocardial injury using high-sensitivity cardiac troponin T in patients with prediabetes: a cross-sectional study · PeerJ · 24 Sep 2026

1. Background parenchymal enhancement is associated with systolic blood pressure in humans.

   “Conversely, BPE correlates with systolic blood pressure (SBP), reflecting vascular tone and perfusion.”

   Humans

   Decoupling Structural and Vascular Biomarkers in Contrast-Enhanced Mammography: A Methodological Synthesis and Perspective · Diagnostics (Basel, Switzerland) · 17 Sep 2026

Background parenchymal enhancement →

1. Systolic blood pressure raises the risk of coronary microvascular disease in humans (OR 1.02, 95% CI 1.00-1.03).

   Humanshigh-altitude training (3,000-3,500 m)n = 1,175

   Correlation between calcium levels and coronary microvascular disease in high-altitude environments: nested case-control study · Frontiers in cardiovascular medicine · 16 Sep 2026

Coronary microvascular disease →

1. Systolic blood pressure raises the risk of electrocardiographic abnormalities in humans (HR 1.17 (95% CI: 1.04-1.31)).

   “Cox regression showed HRs of 1.17 (95% CI: 1.04-1.31) for the persisting high SBP trajectory”

   Humans4-year follow-upn = 2,561

   Trajectories of blood pressure measures and the incidence of electrocardiographic abnormalities: a worker-based cohort study · Frontiers in public health · 10 Sep 2026

1. Systolic blood pressure is associated with cardiovascular mortality in humans.

   Humansin adults without baseline CVD

   Risk-Treatment Discordance and Fatal Cardiovascular Disease: A Nationwide Analysis Using PREVENT Thresholds · American journal of preventive cardiology · 20 Jun 2026