Incident dementia
Disease2 papers3 findings
- Humans1
Associations
3Lithium
downin humans1HR 0.68Low certainty
1 study
Lithium
downin humans1HR 0.68Low certainty
Lithium is associated with incident dementia in humans (HR 0.68, 95% CI 0.60–0.76).
HumansLithium initiation compared with valproate initiation
Starting lithium linked to lower death and dementia risks · Frontiers in neurology · 22 Sep 2026
Apathy
upin humans1
1 study
Apathy
upin humans1
Apathy predicts incident dementia in humans.
Review
Mild behavioral impairment and risk of incident dementia: A systematic review and meta-analysis · Journal of Alzheimer's disease : JAD · 7 Sep 2026
Mild behavioral impairment
upin humans1
1 study
Mild behavioral impairment
upin humans1
Mild behavioral impairment raises the risk of incident dementia in humans.
Reviewwithout dementia at baseline
Mild behavioral impairment and risk of incident dementia: A systematic review and meta-analysis · Journal of Alzheimer's disease : JAD · 7 Sep 2026
Funding
National Institute on AgingUS$806.5k1 grant since 2023
Latest
122Starting lithium linked to lower death and dementia risks
Estimated five-year risks were 6.61% versus 10.65% for death and 3.51% versus 4.85% for dementia, comparing lithium with valproate.Estimated five-year risks were 6.61% versus 10.65% for death and 3.51% versus 4.85% for dementia, comparing lithium with valproate.
Periodontal disease and risk of dementia: a systematic review and meta-analysis
GLP-1 agonists linked to lower dementia risk after COVID-19
GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19…GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19 survivors.
An 11-protein blood score tracks incident dementia risk
In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard…In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard deviation increase.
Reproductive life stages and cognitive outcomes: a systematic review in Latin American and Caribbean women
New postoperative depression links to higher dementia risk
Patients with new depression after major surgery showed an adjusted hazard ratio of 1.59 (95% CI 1.38–1.85) for incident dementia.Patients with new depression after major surgery showed an adjusted hazard ratio of 1.59 (95% CI 1.38–1.85) for incident dementia.
Higher BMI at dementia diagnosis links to lower mortality
Class I obesity was associated with a 27% lower mortality risk compared with normal weight in a large U.S. study of people with incident dementia.Class I obesity was associated with a 27% lower mortality risk compared with normal weight in a large U.S. study of people with incident dementia.
Religious order membership and cognitive function: Evidence for slower late-life decline despite higher incident dementia
HDL particle sizes show contrasting links to dementia risk
In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk…In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14).