Extracellular matrix

Biomarker

2 papers

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Scientific Reports

Drug linked to reduced liver scarring in mice

In mouse experiments, drug use was also associated with partial recovery of signalling in cells lining the liver’s smallest blood vessels.In mouse experiments, drug use was also associated with partial recovery of signalling in cells lining the liver’s smallest blood vessels.

Experiments in miceInterventions
bioRxiv

Cell counts may miss dementia-linked changes in human brains

An observational analysis of human brain tissue compared gene activity and cell proportions across normal cognition, disease-related aging and dementia.An observational analysis of human brain tissue compared gene activity and cell proportions across normal cognition, disease-related aging and dementia.

Preprint: study in peopleMechanisms
Depression and Anxiety

Sleep-linked blood proteins associated with depression risk

Higher sleep-linked protein scores were associated with a lower depression rate during follow-up (hazard ratio 0.660); the abstract did not specify the comparison group.Higher sleep-linked protein scores were associated with a lower depression rate during follow-up (hazard ratio 0.660); the abstract did not specify the comparison group.

Cohort study of 36,852 peopleDepression
Neurobiology of Disease

Spinal fluid proteins linked to Alzheimer’s markers

An observational study of older adults at elevated familial risk linked spinal fluid proteins to a rising Alzheimer’s marker over up to 12 years.An observational study of older adults at elevated familial risk linked spinal fluid proteins to a rising Alzheimer’s marker over up to 12 years.

Cohort study in peopleMechanisms
Research Square

Loss of a matrix enzyme triggers adult bone loss in mice

Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.

Preprint: experiments in miceBones and joints