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Biochimica et Biophysica Acta Molecular Basis of Disease

Low cell-attachment protein levels linked to heart aging in mice

Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.

Experiments in miceMechanisms
Diabetologia

Genetic background shapes cell aging and diabetes in male mice

Male mice carrying the same diabetes-linked mutation developed diabetes on a mixed genetic background, but maintained normal blood sugar on another background.Male mice carrying the same diabetes-linked mutation developed diabetes on a mixed genetic background, but maintained normal blood sugar on another background.

Experiments in miceMechanisms
bioRxiv

RNA version patterns linked to age in adult human brains

An analysis of adult human brain RNA data found age-linked patterns in the mix of RNA versions that persisted after accounting for each gene’s total RNA amount.An analysis of adult human brain RNA data found age-linked patterns in the mix of RNA versions that persisted after accounting for each gene’s total RNA amount.

Preprint: computational studyAI & data
Aging and Disease

Protein injections caused greater weight loss in older mice

Three weeks of protein injections reduced weight in male and female mice, with greater effects in older mice and those fed a high-fat diet.Three weeks of protein injections reduced weight in male and female mice, with greater effects in older mice and those fed a high-fat diet.

Experiments in miceInterventions
bioRxiv

Method maps cell ancestry and gene activity in human blood

The method paired gene activity and DNA-marking measurements at about 10,000 cells per sequencing library, a collection of prepared genetic material.The method paired gene activity and DNA-marking measurements at about 10,000 cells per sequencing library, a collection of prepared genetic material.

Preprint: cohort study of 21,000 peopleAI & data