Papers on epigenetic clock

1,667 papers43 new in 30 days

Wednesday, October 21

Clinical EpigeneticsOct 21

Blood fat links to DNA marks replicated in Korean adults

Links at five previously identified DNA sites were confirmed in two additional Korean groups of 389 and 417 adults.Links at five previously identified DNA sites were confirmed in two additional Korean groups of 389 and 417 adults.

Cross-sectional · 1,527 peopleBiomarkers

Paper

Research SquareOct 21

A scoping review of maternal adverse childhood experiences and offspring epigenetic aging

Preprint: systematic reviewPopulations

Paper

Preprints.orgOct 21

The Activation of NF-κB by the SARS-CoV-2 Spike Protein and Its Role in Epigenetic Age Acceleration, Inflammaging, and, Finally, Senescence

Preprint: reviewCellular senescence

Paper

Tuesday, October 20

DiabetesOct 20

DNA-based aging linked to kidney disease in type 1 diabetes

An observational study using 10 DNA-based aging measures in two cohorts of people with type 1 diabetes linked several measures to kidney disease and its progression.An observational study using 10 DNA-based aging measures in two cohorts of people with type 1 diabetes linked several measures to kidney disease and its progression.

A scarred kidney cross-section with protein clusters sits beside an intact kidney, surrounded by chromatin fibers with dark marks and pale ends.

Cohort studyType 1 diabetes

Paper

SSM - Population HealthOct 20

Moderate helping linked to slower aging measures in the US

In US participants, formal volunteering and informal helping for 1–99 hours a year were associated with slower aging on several DNA-based measures.In US participants, formal volunteering and informal helping for 1–99 hours a year were associated with slower aging on several DNA-based measures.

Informal helping, formal volunteering, and epigenetic age acceleration in the HRS (N = 3919).

Cohort · 3,919 peoplePopulations

Paper

Thursday, October 15

Evolutionary ApplicationsOct 15

Epigenetic Clocks Can Predict Age in the Largemouth Bass-Complex Despite Spatial and Sexual Variation

Experiments in animalsBiomarkers

Paper

Tuesday, October 13

SSM - Population HealthOct 13

Biological aging differed by race within similar work histories

In an observational study of 1,861 adults, employment patterns from ages 18 to 50 were largely unrelated to DNA-based measures of accelerated aging.In an observational study of 1,861 adults, employment patterns from ages 18 to 50 were largely unrelated to DNA-based measures of accelerated aging.

Employment trajectories between ages 18–50 (N = 2147).

Cross-sectional · 1,861 peoplePopulations

Paper

bioRxivOct 13

Ovarian age measures partly shift towards host age in mice

Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.

An ovary-specific transcriptomic clock and multi-omic measures of ovarian aging.

Preprint: mouse studyReproductive system

Paper

Saturday, October 10

Environmental and Molecular MutagenesisOct 10

Associations of Serum Per- and Polyfluoroalkyl Substances (PFAS) With Epigenetic Age and DNA Methylation in US Airport Firefighters

Cross-sectional study of 184 peoplePopulations

Paper

Friday, October 9

Aging CellOct 9

Anti-aging clock results often fail across multiple models

When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.

Epigenetic clock models measuring three different aging interventions.

Computational studyBiomarkers

Paper

Research SquareOct 9

Estimated brain-age gap rises by three years in pregnancy

Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.

Brain cross-sections appear dark blue-green above a pregnant woman and pale blue above a woman holding a toddler’s hand.

Preprint: cohort study of 340 peoplePopulations

Paper

Thursday, October 8

ScienceOct 8

Epigenetic aging runs faster in larger and male dogs

An epigenetic clock built from 894 domestic dogs predicted mortality and linked faster biological aging to larger body size and male sex.An epigenetic clock built from 894 domestic dogs predicted mortality and linked faster biological aging to larger body size and male sex.

Chromatin fibers with dense black methyl marks beneath a large dog contrast with a smaller, sparsely marked fiber beside a small dog.

Study of 894 dogsBiomarkers

Paper

Ageing Research ReviewsOct 8

Mechanisms of Accelerated Biological Aging and Premature Cardiovascular Events in Young and Middle-Aged Post-COVID-19 Survivors

ReviewMechanisms

Paper

Tuesday, October 6

medRxivOct 6

Hormone therapy linked to lower breast cancer mortality

Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death and 1.17 for…Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death and 1.17 for diagnosis.

Preprint: cohort study of 78,209 peopleBreast cancer

Paper

Research SquareOct 6

Low back pain, disability, and biological aging: routinely measurable clinical clocks versus epigenetic clocks (NHANES)

Forest plot of adjusted odds ratios per SD (95% CI) for low back pain across the full clock panel, highlighting the same-name pair (clinical PhenoAge vs DNAm-PhenoAge); reference line at OR=1.

Preprint: cross-sectional study of 2,532 peopleLow back pain

Paper

Monday, October 5

bioRxivOct 5

Disease mutations shift epigenetic age in organoids

In a preprint using iPSC-derived organoids, serial passaging re-established aging trajectories while disease-associated mutations drove additional cell-intrinsic shifts…In a preprint using iPSC-derived organoids, serial passaging re-established aging trajectories while disease-associated mutations drove additional cell-intrinsic shifts in epigenetic age.

Epigenetic age is reset during iPSC reprogramming and re-accumulates in alveolosphere organoids over extended culture.

Preprint: experiments in human cellsEpigenetic age

Paper

Friday, October 2

bioRxivOct 2

Early life stress accelerates epigenetic aging in zebra finches

Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.

Data structure and RRBS-based clock construction.

Preprint: experiments in zebra finchesMechanisms

Paper

Aging CellOct 2

Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers

In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.

Associations of 23 ageing biomarkers with all‐cause mortality in the LBC1936.

Cohort study of 861 peopleBiomarkers

Paper

Genome MedicineOct 2

Blood cell composition explains substantial variation in DNA methylation age

Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.

$Distribution of age and cell fractions.$

Cohort study of 18,859 peopleEpigenetic age

Paper

Thursday, October 1

medRxivOct 1

Epigenetic puberty index tracks biological aging and adult health risks

A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.

Preprint: cohort study of 18,676 peopleBiomarkers

Paper

GeroScienceOct 1

Associations between socioeconomic position index and epigenetic aging in NHANES

Cross-sectional study in peoplePopulations

Paper

Wednesday, September 30

Journal of the National Cancer InstituteSep 30

Exercise linked to slower epigenetic aging in breast cancer survivors

In a randomized trial of 124 breast cancer survivors, a 12-month exercise intervention slowed epigenetic aging measured by GrimAge2 and DNAmFitAge compared to a wellness…In a randomized trial of 124 breast cancer survivors, a 12-month exercise intervention slowed epigenetic aging measured by GrimAge2 and DNAmFitAge compared to a wellness control.

Figure from Journal of the National Cancer Institute

Randomized trial in 124 peopleExercise

Paper

Annual Review of PsychologySep 30

A Conceptual Framework for Understanding the Effects of Stress on Epigenetic Aging

ReviewPopulations

Paper

Aging and DiseaseSep 30

Older adults with preserved cognition show slower biological aging and longer telomeres

An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres.An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres.

Two rows of older people stand beneath strings of nucleosomes with red telomeres, which are longer on the left and shorter on the right.

Cross-sectional study of 80 peopleBiomarkers

Paper

Central Asian Journal of Medical Hypotheses and EthicsSep 30

EPIGENETICS OF LIFESTYLE IN NONCOMMUNICABLE DISEASES: IMPLICATIONS FOR PERSONALIZED PREVENTION

ReviewMechanisms

Paper

Tuesday, September 29

medRxivSep 29

Accelerated epigenetic aging predicts major depression and brain changes after trauma

Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity shifts in adults over…Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity shifts in adults over 35.

Preprint: cohort study of 706 peopleGrimAge

Paper

Saturday, September 26

BiomedicinesSep 26

Aging Biology of Bone-to-Tendon Healing and the Epigenetic Clock: A Biological-Age Readout of Rotator Cuff Healing Capacity

Tendon-to-bone interface healing capacity is placed at the center, surrounded by the eight aging-regulated determinant domains (progenitor competence, cellular senescence, inflammaging, ECM/AGEs,…

ReviewEpigenetic clock

Paper

BiomedicinesSep 26

Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health

Influence of keystone gut microorganisms on brain health via the gut–brain axis.

ReviewBiomarkers

Paper

GeroScienceSep 26

Diet benefits for epigenetic aging may reflect familial factors

In Danish twins, adherence linked cross-sectionally to slower DunedinPACE, but within-pair and longitudinal analyses attenuated the associations over 12 years.In Danish twins, adherence linked cross-sectionally to slower DunedinPACE, but within-pair and longitudinal analyses attenuated the associations over 12 years.

Cohort study in peoplePopulations

Paper

Friday, September 25

PsyArXivSep 25

Exploring links between type- and timing-specific characteristics of childhood maltreatment and epigenetic aging in formerly out-of-home placed young adults

Preprint: cohort study of 116 peoplePopulations

Paper