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Epigenetic clock

Papers on epigenetic clock

1,667 papers43 new in 30 days

Thursday, November 5

Wednesday, November 4

Tuesday, November 3

PNAS

DNA-based aging measures rose during the COVID-19 pandemic

An aging-pace measure showed an estimated rise of 0.13 on the study’s statistical scale from prepandemic levels across children, adolescents and adults.An aging-pace measure showed an estimated rise of 0.13 on the study’s statistical scale from prepandemic levels across children, adolescents and adults.

Figure from PNAS
Cohort · 1,028 peoplePopulations
Paper

Monday, November 2

Sunday, November 1

Friday, October 30

Nature Methods

DNA-end correction linked to better cell-free DNA profiling

The JEEPERS framework detected and corrected false methylation signals introduced when cell-free DNA was prepared for sequencing.The JEEPERS framework detected and corrected false methylation signals introduced when cell-free DNA was prepared for sequencing.

Figure from Nature Methods
Computational studyBiomarkers
Paper

Thursday, October 29

GeroScience

Low-dose aspirin did not prevent functional decline in older adults

Women assigned aspirin had a small extra decline versus placebo, with an estimated effect of minus 0.006 on the capacity score; men showed no effect.Women assigned aspirin had a small extra decline versus placebo, with an estimated effect of minus 0.006 on the capacity score; men showed no effect.

Figure from GeroScience
Randomized trial · 18,581 peopleAspirin
Paper

Wednesday, October 28

Tuesday, October 27

Monday, October 26

ESC Congress 2026 Abstract

Replacing calendar age did not improve a heart risk model

For deaths from any cause, prediction scores were 0.744 using calendar age and 0.011–0.081 lower after researchers substituted DNA-based age.For deaths from any cause, prediction scores were 0.744 using calendar age and 0.011–0.081 lower after researchers substituted DNA-based age.

A looping chromatin fiber bears dense and sparse methyl marks above similar groups of upright people beside hearts with visible chambers.
Cohort · 1,516 peopleBiomarkers
Paper

Sunday, October 25

Friday, October 23

bioRxiv

Blocking an RNA counters aging-related gene activity in cells

Cell experiments found that inhibiting the RNA lowered DNA-based age estimates but made DNA markings less consistent with cell identity.Cell experiments found that inhibiting the RNA lowered DNA-based age estimates but made DNA markings less consistent with cell identity.

A large cell has loosely marked chromatin and a bound RNA strand beside a smaller gray cell with denser markings and more surrounding RNA strands.
Preprint: animal cell studyMechanisms
Paper

Thursday, October 22

Annals of Neurology

Frontotemporal dementia linked to faster aging on a DNA clock

Patients scored 1.17 higher than controls on a blood DNA measure of accelerated aging in an adjusted analysis of two observational cohorts.Patients scored 1.17 higher than controls on a blood DNA measure of accelerated aging in an adjusted analysis of two observational cohorts.

Figure from Annals of Neurology
Meta-analysisFrontotemporal dementia
Paper