Nutrition

10 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Institute on Aging and others

Human trial1
Humans3
Model organisms1

Outcomes

Inflammation

downin reviews1

1 study

Nutrition decreases inflammation.
“Specifically, these strategies aim to reduce inflammation, preserve mitochondrial function to modulate ROS production, and protect macromolecules from oxidative stress.”
Review
Nutritional Strategies and Aging: Current Evidence and Future Directions
Molecules (Basel, Switzerland)24 Feb 2026

Associations

Aβ40

upin humans1

1 study

Nutrition is associated with Aβ40 in humans.
“Nutrition emerged as a key determinant, strongly associating with Aβ40 in AD”
Humansin AD
Impact of social determinants of health on ATN biomarkers and neurodegeneration in the ReDLat cohort
AAIC 2025 abstract10 Jan 2026