GLA
Gene3 papers6 findingsHGNC 4296NCBI Gene 2717Taxon 9606
In one human study, GLA increases pacemaker implantation and right bundle branch block risk in males, without affecting atrial fibrillation. It also increases PR interval in IVS4+919G>A carriers.
- Humans2
- Cells1
Effects
4PR interval
upin humans1
1 study
PR interval
upin humans1
GLA increases PR interval in humans.
Humansin IVS4+919G>A carriers
Progressive conduction system disease preceding hypertrophy in IVS4+919G>A Fabry variant: a population-based electrocardiographic study · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 22 Sep 2026
Atrial fibrillation
no changein humans1HR 1.435
1 study
Atrial fibrillation
no changein humans1HR 1.435
GLA has no effect on atrial fibrillation in humans (HR 1.435, 95% CI 0.69-2.96).
Humansmales
Progressive conduction system disease preceding hypertrophy in IVS4+919G>A Fabry variant: a population-based electrocardiographic study · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 22 Sep 2026
DunedinPACE
upin humans1
1 study
DunedinPACE
upin humans1
GLA increases DunedinPACE in humans (p = 0.0328).
Humansin Anderson-Fabry disease patientsn = 32
Epigenetic aging and autosomal methylation remodeling in Anderson-Fabry disease · Experimental gerontology · 9 Sep 2026
Fabry disease
mediatesin human cells1
1 study
Fabry disease
mediatesin human cells1
GLA mediates Fabry disease in human cells.
CellsCRISPR-Cas9 mutation in FEKOPTCs
Generation of the functionally enhanced proximal tubular cells from human iPSC-derived kidney organoids · Experimental & molecular medicine · 3 Sep 2026
Associations
2Pacemaker implantation
upin humans1HR 9.197
1 study
Pacemaker implantation
upin humans1HR 9.197
GLA raises the risk of pacemaker implantation in humans (HR 9.197, 95% CI 2.88-29.31).
Humansmales
Progressive conduction system disease preceding hypertrophy in IVS4+919G>A Fabry variant: a population-based electrocardiographic study · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 22 Sep 2026
Right bundle branch block
upin humans1HR 9.286
1 study
Right bundle branch block
upin humans1HR 9.286
GLA raises the risk of right bundle branch block in humans (HR 9.286, 95% CI 5.16-16.70).
Humansmales
Progressive conduction system disease preceding hypertrophy in IVS4+919G>A Fabry variant: a population-based electrocardiographic study · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 22 Sep 2026