Research Square

More activity linked to lower risk of daily living problems or death

Relative risks with sustained increases versus persistently lower activity were 0.776 in the US, 0.764 in Europe and 0.725 in South Korea; below 1 means lower risk.

Paper by Zewei Chen, Fengying Yu, Yiyuan Huang, +2 more authorsZhenfei Fang · Second Xiangya Hospital of Central South University
Upright faceless people form a large dark blue-green walking group beside a smaller gray standing group, with white silhouettes interspersed.

Our read

Populations
Studied:
Preprint: cohort study of 19,204 previously less active, independent older adults, about four years
What changed:
Daily living problems or death were lower with increased versus lower activity: US 7.08, Europe 8.15, South Korea 4.89 percentage points
The catch:
Better underlying health among people increasing activity could explain some of the lower risk
In the record:
The 3,288th paper on physical activity with results in people; 6,950 on record in all.

Editor of record: Boris Djordjevic · AgingResearch.News

Follow @agingbrief

The 19,204 adults aged 65 or older in three longitudinal cohorts were previously less active and independent in five basic activities of daily living. In this target trial emulation, they contributed 43,754 eligible entries. Researchers compared increased activity frequency maintained at the first follow-up with persistently lower frequency.

Over two subsequent visits, generally about four years, sustained increases were associated with a risk of daily living problems or death lower by 7.08 percentage points in the US cohort, 8.15 in Europe and 4.89 in South Korea. Deaths accounted for a substantial part of these differences. Findings for daily living problems alone were less consistent.

Why it matters

Maintaining independence and survival are central goals of healthy aging. The authors said the findings support evaluating sustained activity support programs, with attention to how many people they reach and help maintain increased activity.

Caveats

People who increased activity may have been healthier in ways the analysis could not account for. The preprint, which has not been peer-reviewed, covered only adults aged 65 or older who began independent in five basic daily activities.

Comments

Be the first to comment.

The paper

Increasing and maintaining physical activity in later life: a target trial emulation of daily living problems or death across three ageing cohorts

Zewei Chen, Fengying Yu, Yiyuan Huang, +2 more authorsZhenfei Fang

Second Xiangya Hospital of Central South University

Research Square, Nov 11, 2026, Open access, Preprint, not yet peer-reviewed

doi.org/10.21203/rs.3.rs-11396575/v1