Heart and blood vessels
Body system452 papersUBERON 0004535
- Human trial20
- Humans276
- Animals29
- Cells3
- In silico20
Latest
451Combined frailty and metabolic index tracks multimorbidity risk
Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic…Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic multimorbidity.
Effect of interventions for stress management on blood pressure changes in healthy adults: a systematic review and meta-analysis
Sex, Racial/Ethnic, and Regional Disparities in Mortality Involving Both Cardiac Arrest and Type 2 Diabetes Mellitus Among U.S. Adults, 1999-2020
Human aortic elastin degrades with age in males but not females
In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not…In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females.
Metabolic signature links frailty to coronary artery disease
A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year…A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year follow-up.
Higher neuroticism links to broad disease risks in Chinese adults
In 25,041 Chinese adults, high neuroticism scores were linked to 1.17- to 1.81-fold higher risks of major physical and mental conditions compared to…In 25,041 Chinese adults, high neuroticism scores were linked to 1.17- to 1.81-fold higher risks of major physical and mental conditions compared to low scores.
TMEM174 deficiency shortens lifespan and stiffens vessels in mice
Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification…Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality.
Calcium overload impairs muscle regeneration by driving sustained NFAT signaling
Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.
Rapamycin improves efferocytosis and reduces plaques in mice
In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ±…In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ± 0.02 to 1.37 ± 0.15.
Covariate Selection in Physical Activity Epidemiology: Too Little, Too Much, or Just Right?
Depressive symptom profiles and risk of cardiometabolic disease incidence
Inflammatory burden is linked to incident heart failure
In 6,785 adults, adjusting for four inflammatory biomarkers reduced the Black-White heart failure log-hazard difference by 57.5% relative to a…In 6,785 adults, adjusting for four inflammatory biomarkers reduced the Black-White heart failure log-hazard difference by 57.5% relative to a clinical model.
Retinal vascular changes track mortality risk in humans
Increased retinal fractal dimension carried a mortality hazard ratio of 0.92 per standard deviation, whereas arteriolar widening carried a hazard…Increased retinal fractal dimension carried a mortality hazard ratio of 0.92 per standard deviation, whereas arteriolar widening carried a hazard ratio of 1.09.