Amputation

Intervention1 paper2 findings

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

2 independent labs in 1 country

Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development and 1 more

  • Humans1

Outcomes

1

Stress symmetry

downin mice1

1 study
  1. Amputation decreases stress symmetry in mice.

    Animalsfollowing amputationdigit tip

    Multiscale analysis reveals distinct temporal trajectories of morphological reconstruction and mechanical maturation during mouse digit tip regeneration · Acta biomaterialia · 19 Aug 2026

Associations

1

fgf20a

upin zebrafish1

1 study
  1. Amputation is associated with fgf20a in zebrafish.

    Animalsfin regenerationepidermis

    Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration · Nature physics · 24 Aug 2026

fgf20a →

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