Sedentary behavior

1. Sedentary behavior has no effect on VO2max in humans (β: -1.46, 95% CI: -4.74 to 1.83).

   Human trialhigh-intensity group compared with usual care6 months

   Interaction Between Exercise Intensity and Sedentary Behavior on VO2max Change in Patients with De Novo Parkinson Disease: The Study in Parkinson Disease of Exercise (SPARX) Phase 2 Randomized Clinical Trial · medRxiv · 2 Oct 2026 · Preprint

VO2max →

1. Sedentary behavior is associated with VO2max in humans (-2.51 mL/kg/min per 10% increase in sedentary time, 95% CI: -4.53 to -0.48).

   Human trialcomplete cases sensitivity analysis in moderate-intensity group compared with usual care6 months

   Interaction Between Exercise Intensity and Sedentary Behavior on VO2max Change in Patients with De Novo Parkinson Disease: The Study in Parkinson Disease of Exercise (SPARX) Phase 2 Randomized Clinical Trial · medRxiv · 2 Oct 2026 · Preprint

VO2max →

1. Sedentary behavior is associated with tinnitus in humans (aPR 1.27, 95% CI 1.10-1.47).

   “Longer sedentary time was associated with a modestly higher prevalence of current tinnitus, not accounted for by the measured covariates.”

   Humansfully adjustedfemalesn = 7,239

   Sedentary Time and Current Tinnitus in Midlife Korean Women (Aged 40 to 64 Years): A Cross-Sectional Analysis from KNHANES 2014-2018 · Healthcare (Basel, Switzerland) · 20 Sep 2026

Tinnitus →