RUNX2

Gene9 papers3 findingsHGNC 10472NCBI Gene 860Taxon 9606

Humans1
Animals8

Interventions

1

Artocarpus integer

upin rats1Very low certainty

1 study

Artocarpus integer increases RUNX2 in rats.
Animalsin ovariectomized rats
Bioactive Phytochemicals from Artocarpus integer Leaves Improve Bone-Related Outcomes in Ovariectomized Rats: An Integrated LC-HRMS, Network Pharmacology, and Experimental Study · Nutrients · 2 Sep 2026

Artocarpus integer →

Upstream

1

MAPK14

upin mice1

1 study

MAPK14 increases RUNX2 in mice.
Animalshyperlipidemic agingaorta
Smooth Muscle Cell MAPK14 Promotes Vascular Calcification During Hyperlipidemic Aging · Cells · 8 Sep 2026

Associations

1

Type 2 diabetes

downin humans1OR 0.998

1 study

RUNX2 lowers the risk of type 2 diabetes in humans (OR 0.998).
Humanstwo-sample MR using whole-blood eQTLs
Identification of Progressive Islet Biomarkers for Type 2 Diabetes by Integrated Transcriptomics and Mendelian Randomization: Alterations Spanning the Normal Glucose Tolerance-Impaired Glucose Tolerance-Type 2 Diabetes Continuum · Biomedicines · 18 Aug 2026

Type 2 diabetes →

Latest

9

CellsAnimals24 Sep

Smooth Muscle Cell MAPK14 Promotes Vascular Calcification During Hyperlipidemic Aging

Research SquareAnimalsPreprint18 Sep

Lactylation of histone variant MacroH2A1 at K134 regulates osteogenic differentiation of bone marrow mesenchymal stem cells

Stem cell differentiation

NutrientsAnimals15 Sep

Bioactive Phytochemicals from Artocarpus integer Leaves Improve Bone-Related Outcomes in Ovariectomized Rats: An Integrated LC-HRMS, Network Pharmacology, and Experimental Study

Bones and joints

ACS Biomaterials Science & EngineeringAnimals8 Sep

Synergistic Tuning of Pore Architecture and Mechanical Properties in a Biomimetic COL-HA-PVA Hydrogel Directs BMSC Chondrogenesis for Osteochondral Regeneration

npj Drug DiscoveryAnimals8 Sep

RUNX2 inhibitor CADD522 improves bone microarchitecture and lipid metabolism in post-menopausal bone loss

Bones and joints

GeroScienceAnimals3 Sep

Targeting cellular senescence mitigates chemotherapy-induced bone loss in young and aged mice

Bones and joints

Journal of Materials Chemistry BAnimals1 Sep

Construction of biomimetic hydroxyapatite bilayer scaffolds via DLP 3D printing for bio-root regeneration

BiomedicinesHumans27 Aug

Identification of Progressive Islet Biomarkers for Type 2 Diabetes by Integrated Transcriptomics and Mendelian Randomization: Alterations Spanning the Normal Glucose Tolerance-Impaired Glucose Tolerance-Type 2 Diabetes Continuum

Type 2 diabetes

Food & FunctionAnimals26 Aug

Pearl mussel (Hyriopsis cumingii)-derived exosome-like nanovesicles promote osteogenesis and alleviate ovariectomy-induced bone loss in mice

Bones and joints