Dendrobine

2 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: Department of Science and Technology of Sichuan Province and 2 more

Animals2

Outcomes

6

Wnt/β-catenin signalling

upin cells1

1 study

Dendrobine activates wnt/β-catenin signalling in cells.
“Dendrobine activated the Wnt/β-catenin pathway by suppressing the phosphorylation level of GSK-3β at Tyr216 site”
Cells
Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis
Frontiers in pharmacology3 Dec 2025

More on Wnt/β-catenin signalling

RUNX2

upin mice1

1 study

Dendrobine increases RUNX2 in mice.
“Dendrobine increased Runx2, alkaline phosphatase, and osteocalcin expression in ovariectomy (OVX) mice.”
Animalsin OVX mice
Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis
Frontiers in pharmacology3 Dec 2025

Loss of cancellous bone

downin mice1

1 study

Dendrobine decreases loss of cancellous bone in mice.
“In OVX mice, dendrobine attenuated the loss of cancellous bone”
Animalsin OVX mice
Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis
Frontiers in pharmacology3 Dec 2025

Mitophagy

upin mice1

1 study

Dendrobine increases mitophagy in mice.
“Den improved mitophagy levels, as evidenced by increased mitochondrial mean length and mitophagy-associated proteins (PINK1, Parkin, NIX, and BNIP3)”
Animalsin diabetic kidney disease
Dendrobine ameliorates mitophagy-mediated endothelial senescence in diabetic kidney disease through activating the SIRT1/FOXO3a pathway
Chinese medicine18 Oct 2025

More on Mitophagy

Senescence-associated beta-galactosidase

downin mice1

1 study

Dendrobine decreases senescence-associated beta-galactosidase in mice.
“SA-β-Gal staining showed that Den reduced the positive area of SA-β-Gal.”
Animalsin DKD mice
Dendrobine ameliorates mitophagy-mediated endothelial senescence in diabetic kidney disease through activating the SIRT1/FOXO3a pathway
Chinese medicine18 Oct 2025

More on Senescence-associated beta-galactosidase

Renal injury

downin mice1

1 study

Dendrobine protects against renal injury in mice.
“Biochemical and histological analyses indicated Den protected against renal injury in DKD mice.”
Animalsdiabetic kidney disease8 weeks
Dendrobine ameliorates mitophagy-mediated endothelial senescence in diabetic kidney disease through activating the SIRT1/FOXO3a pathway
Chinese medicine18 Oct 2025

Latest

1 in 12 months

Frontiers in Pharmacology19 Dec

Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis

Experiments in micePostmenopausal osteoporosis

Chinese Medicine18 Oct

Dendrobine ameliorates mitophagy-mediated endothelial senescence in diabetic kidney disease through activating the SIRT1/FOXO3a pathway

Experiments in miceDiabetic kidney disease