Calcifediol

1. Calcifediol mediates cognitive function in humans (24% mediated).

   “25(OH)D, an oxidative stress indicator, partially mediated 24% of the association between AIP and the CERAD total score.”

   Humansbetween AIP and the CERAD total score

   Association of the atherogenic index of plasma with cognitive function and oxidative stress: A population-based study

   Journal of Alzheimer's disease : JAD·7 May 2025

1. Calcifediol is associated with Huntington's disease in humans.

   “low serum levels of 25-hydroxy Vitamin D3 (25(OH)D3 or calcidiol), the major circulating form of VD, is associated with an increased risk of Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD)”

   Review

   Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders

   Molecular neurobiology·19 Feb 2024

More on Huntington's disease

1. Calcifediol is associated with Parkinson's disease in humans.

   “low serum levels of 25-hydroxy Vitamin D3 (25(OH)D3 or calcidiol), the major circulating form of VD, is associated with an increased risk of Alzheimer's disease (AD), Parkinson's disease (PD)”

   Review

   Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders

   Molecular neurobiology·19 Feb 2024

More on Parkinson's disease

1. Calcifediol is associated with Alzheimer's disease in humans.

   “low serum levels of 25-hydroxy Vitamin D3 (25(OH)D3 or calcidiol), the major circulating form of VD, is associated with an increased risk of Alzheimer's disease”

   Review

   Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders

   Molecular neurobiology·19 Feb 2024

More on Alzheimer's disease