Glycerophosphocholine
Glycerophosphocholine has been studied in 3 papers since 2022: none in people yet, 2 in animals, 1 review; 1 in the past year. The research so far is in animals. The newest paper, Jun 30, 2026: “Immunomodulatory Properties of Choline and its Dietary Forms throughout the Lifespan”.
3 papers study it7 findingsUpdated
None of its findings points the other way.
- 2 independent labs in 1 country
- Funders: National Natural Science Foundation of China and 4 more
- Model organisms2
What did studies of Glycerophosphocholine find?
5Studies of Glycerophosphocholine measured 5 outcomes; the most studied are oxidative stress and ROS signaling (2 studies), lifespan (2) and fecundity (1).
Oxidative stress and ROS signaling
downin S. kraussei1downin worms1
2 studies
Oxidative stress and ROS signaling
downin S. kraussei1downin worms1
Glycerophosphocholine decreases oxidative stress and ROS signaling in S. kraussei.
“GPC significantly inhibited reactive oxygen species (ROS) and lipofuscin accumulation”
Model organisms50 mM
Anti-aging effect of glycerophosphocholine in Steinernema kraussei 0657L
Frontiers in physiology
Glycerophosphocholine decreases oxidative stress and ROS signaling in worms.
“GPC significantly inhibits the reactive oxygen species (ROS) accumulation in worms”
Model organisms
Metabolites
Lifespan
upin S. kraussei1upin worms1+55%
2 studies
Lifespan
upin S. kraussei1upin worms1+55%
Glycerophosphocholine extends lifespan in S. kraussei (+54.55%).
“the lifespan of S. kraussei 0657L was significantly prolonged by 50 mM GPC treatment, which was 54.55% longer than that of the control (0 mM GPC).”
Model organisms50 mM
Anti-aging effect of glycerophosphocholine in Steinernema kraussei 0657L
Frontiers in physiology
Glycerophosphocholine extends lifespan in worms.
“GPC extends lifespan”
Model organisms
Metabolites
Fecundity
no changein S. kraussei1
1 study
Fecundity
no changein S. kraussei1
Glycerophosphocholine has no effect on fecundity in S. kraussei.
“the body size and fecundity of S. kraussei 0657L had little changed.”
Model organisms50 mM
Anti-aging effect of glycerophosphocholine in Steinernema kraussei 0657L
Frontiers in physiology
Reproductive ability
no changein worms1
1 study
Reproductive ability
no changein worms1
Glycerophosphocholine has no effect on reproductive ability in worms.
“GPC treatment has no adverse effect on nematodes' reproductive abilities and body length”
Model organisms
Metabolites
Physical function
upin worms1
1 study
Physical function
upin worms1
Glycerophosphocholine improves physical function in worms.
“improves exercise capacity during aging”
Model organisms
Metabolites