Conjugated equine estrogens
Intervention3 papers4 findings
- Human trial1
- Humans1
Outcomes
4Liver cancer
no changein humans1HR 0.75Moderate certainty
1 study
Liver cancer
no changein humans1HR 0.75Moderate certainty
Conjugated equine estrogens have no effect on liver cancer in humans (HR 0.75; 95% CI, 0.34-1.63).
Human trial0.625 mg/dnearly 24 yearsfemalesn = 10,739
Menopausal hormone therapy and primary liver cancer: long-term follow-up of the women's health initiative randomized trials · British journal of cancer · 16 Sep 2026
Systolic blood pressure
upin humans1High certainty
1 study
Systolic blood pressure
upin humans1High certainty
Conjugated equine estrogens increase systolic blood pressure in humans.
ReviewWHI-HT analysesfemales
Cardiovascular and Metabolic Outcomes of Hormone Replacement Therapy in Women Aged 65 Years and Older: A Systematic Review of Randomized Clinical Trials · Clinical pharmacology : advances and applications · 9 Sep 2026
Triglyceride
upin humans1High certainty
1 study
Triglyceride
upin humans1High certainty
Conjugated equine estrogens increase triglyceride in humans.
ReviewWHI-HT analysesfemales
Cardiovascular and Metabolic Outcomes of Hormone Replacement Therapy in Women Aged 65 Years and Older: A Systematic Review of Randomized Clinical Trials · Clinical pharmacology : advances and applications · 9 Sep 2026
Low-density lipoprotein cholesterol
downin humans1High certainty
1 study
Low-density lipoprotein cholesterol
downin humans1High certainty
Conjugated equine estrogens decrease low-density lipoprotein cholesterol in humans.
ReviewWHI-HT analysesfemales
Cardiovascular and Metabolic Outcomes of Hormone Replacement Therapy in Women Aged 65 Years and Older: A Systematic Review of Randomized Clinical Trials · Clinical pharmacology : advances and applications · 9 Sep 2026