BiomarkersHumans13,222 adultsCohort study

Association of CKM Phenotypic Age Acceleration and APOE Genotype with Risk of Cognitive Decline in U.S. Adults Aged 50 and Over

AAIC 2025 Abstract

Abstract

Background: The association of cardio‐kidney‐metabolic (CKM) syndrome with cognitive decline and APOE genotype remains unclear. This study aimed to investigate the association of CKM phenotypic age (CKMAge) and cognitive decline, considering the effect modification by Apolipoprotein E (APOE) genotype in U.S. adults.

The paper

Liu L, Hou J, Michael YL

AAIC 2025 Abstract · 24 Dec 2025 · CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70856_102835