3 papers3 findings
Senotherapies
downin humans1
Senotherapies protect against age-related pathologies in humans.
“senotherapies designed to eliminate senescent cells or block SASP signaling have emerged as promising interventions to ameliorate age-related pathologies”
Review
Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations
MedComm18 Dec 2025
Dietary restriction
downin reviews1
Dietary restriction decreases age-related pathologies.
“This increase in longevity by dietary restriction (DR) is coupled to profound beneficial effects on age-related pathology.”
Review
Aging and survival: the genetics of life span extension by dietary restriction
Annual review of biochemistry1 Jan 2008
Autophagy
downin reviews1
Autophagy protects against age-related pathologies.
“A functional autophagy pathway, characterized by cell- and tissue-specific basal autophagy activity, is crucial for the cell's successful response to aging and the mitigation of age-related pathologies.”
Review
Expert opinion on therapeutic targets16 Nov 2025
One lung immune cell population increased more than 10-fold in old mice compared with younger mice.One lung immune cell population increased more than 10-fold in old mice compared with younger mice.
Researchers identified a transient senescent-like monocyte state governed by the transcription factor AP-1 that primes cells toward inflammatory and sepsis-associated…Researchers identified a transient senescent-like monocyte state governed by the transcription factor AP-1 that primes cells toward inflammatory and sepsis-associated states.
Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses.Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses.
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.