In 4,427 older Chinese adults followed across three survey waves, lower cognitive function linked to widowhood occurred primarily in passive and…In 4,427 older Chinese adults followed across three survey waves, lower cognitive function linked to widowhood occurred primarily in passive and television-dominant sedentary activity patterns.
In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical…In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical frailty, versus 0.224 toward further deterioration.
In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia…In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia (hazard ratio 1.30). In 2,606 Framingham Heart Study Offspring cohort participants (mean age 66 years), researchers examined how three DNA…
In 132 older adults, greater neighborhood deprivation was associated with lower whole-brain cerebrovascular reactivity, independent of traditional…In 132 older adults, greater neighborhood deprivation was associated with lower whole-brain cerebrovascular reactivity, independent of traditional vascular risks and Alzheimer's pathology.
Carotid intima-media thickness mediated 3.64% of the link between cardiovascular health metrics and disease events in 358,650 adults.Carotid intima-media thickness mediated 3.64% of the link between cardiovascular health metrics and disease events in 358,650 adults. A study evaluated 358,650 adults aged 35 to 75 years without baseline cardiovascular disease from a national cohort in China.
In 5,828 couples tracked from 2011 to 2020, cognitive decline correlated within pairs at r = 0.567 and diverged across joint frailty and depression…In 5,828 couples tracked from 2011 to 2020, cognitive decline correlated within pairs at r = 0.567 and diverged across joint frailty and depression trajectories. A study of 5,828 couples analyzed shared changes in physical and mental health using data from the China Health and Retirement…
In a matched cohort, patients with delirium within 14 days of brain trauma had higher two-year risk of dementia (hazard ratio 2.47).In a matched cohort, patients with delirium within 14 days of brain trauma had higher two-year risk of dementia (hazard ratio 2.47). Researchers analyzed records from the TriNetX global federated research network to track cognitive outcomes in patients with traumatic brain injury (TBI).
Compared with never-smokers, ever-smokers of waterpipe had about a 60% higher risk of cardiovascular death, with a hazard ratio of 1.57.Compared with never-smokers, ever-smokers of waterpipe had about a 60% higher risk of cardiovascular death, with a hazard ratio of 1.57. In a cohort of 35,646 Vietnamese adults aged 18 and older, ever-smoking waterpipe was associated with an increased risk of cardiovascular disease death.
Prior hospital-treated infection linked to lower general cognition (β = -0.11 SD), while each 1-SD higher cognitive score predicted a 36% lower risk…Prior hospital-treated infection linked to lower general cognition (β = -0.11 SD), while each 1-SD higher cognitive score predicted a 36% lower risk of future infection. In a study of 1,159 adults aged 65 and older from the English Longitudinal Study of Ageing, researchers investigated how…
Across 468,266 adults followed for 13 years, genetics drove initial disease onset, whereas clinical and lifestyle factors dominated subsequent…Across 468,266 adults followed for 13 years, genetics drove initial disease onset, whereas clinical and lifestyle factors dominated subsequent polyvascular spread and mortality.
Across 207,887 participants in a meta-analysis, current smoking was associated with all-cause dementia risk exclusively among APOE ε4 noncarriers.Across 207,887 participants in a meta-analysis, current smoking was associated with all-cause dementia risk exclusively among APOE ε4 noncarriers. In a cohort of 173,366 UK Biobank participants without dementia followed for a median of 13 years, researchers evaluated how smoking burden and…
Among non-smoking non-drinkers, adults with no schooling had a mortality rate ratio of 2.76 in men and 2.93 in women compared to higher education.Among non-smoking non-drinkers, adults with no schooling had a mortality rate ratio of 2.76 in men and 2.93 in women compared to higher education. In a prospective study of 500,810 adults aged 35 and older in Chennai, India, researchers evaluated how social inequality, smoking, and alcohol…
In 39,468 women, each 0.1-unit rise in miscarriage propensity was associated with a hazard ratio of 1.38 for incident type 2 diabetes.In 39,468 women, each 0.1-unit rise in miscarriage propensity was associated with a hazard ratio of 1.38 for incident type 2 diabetes. In 42,313 gravid Sister Study participants, researchers evaluated whether a history-based measure of miscarriage propensity predicts subsequent gestational…
In 25,041 Chinese adults, high neuroticism scores were linked to 1.17- to 1.81-fold higher risks of major physical and mental conditions compared to…In 25,041 Chinese adults, high neuroticism scores were linked to 1.17- to 1.81-fold higher risks of major physical and mental conditions compared to low scores. In a prospective study of 25,041 Chinese adults from five urban and five rural regions, researchers evaluated the health patterns…
Across two aging cohorts spanning normal cognition to mild Alzheimer’s disease, higher education tracked with better cognitive performance even after…Across two aging cohorts spanning normal cognition to mild Alzheimer’s disease, higher education tracked with better cognitive performance even after adjusting for multimodal brain pathology.
In a longitudinal study of 16,780 older adults over eight years, cardiometabolic multimorbidity and depression together were tied to steeper rises in…In a longitudinal study of 16,780 older adults over eight years, cardiometabolic multimorbidity and depression together were tied to steeper rises in daily living disability. In a longitudinal study of 16,780 adults aged 45 and older from the China Family Panel Studies tracked between 2012…
Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident…Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident Alzheimer’s disease risk. In human health records and cortical organoids, researchers evaluated aspirin as a repurposed candidate against…
