AI & data
Thu 1 Oct16 papers
Rapid auditory readout tracks nerve loss in gerbils
A machine-learning model trained on gerbil synapse counts separated age groups above chance when tested on 56 human listeners.A machine-learning model trained on gerbil synapse counts separated age groups above chance when tested on 56 human listeners. In Mongolian gerbils with histologically verified cochlear neural degeneration, researchers evaluated dynamic amplitude-modulated envelope following responses that…
Model infers spatial neighborhoods in dissociated single cells
The computational tool predicted cellular proximity across brain regions and identified age-associated neighborhood remodeling in an 8-month Alzheimer…The computational tool predicted cellular proximity across brain regions and identified age-associated neighborhood remodeling in an 8-month Alzheimer dataset. In brain tissue transcriptomic datasets, researchers tested ProxiNet, a computational framework designed to infer cellular…
Blood methylation framework maps dependencies between aging hallmarks and organ aging
A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand…A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand participants. In a preprint, researchers analyzed blood DNA-methylation profiles from 656 discovery and 1,394 replication human participants to…
Long-read platforms support large DNA methylation predictors
Across human blood samples, 19 of 21 predictors with over 1,000 CpGs reached correlations above 0.8 between Oxford Nanopore and PacBio duplicate…Across human blood samples, 19 of 21 predictors with over 1,000 CpGs reached correlations above 0.8 between Oxford Nanopore and PacBio duplicate pairs. Using human blood samples from two population cohorts, researchers evaluated how long-read sequencing platforms capture DNA methylation…
Organ age acceleration and mortality risk reflect distinct biological processes
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from…Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality. In a preprint analyzing 409,206 human participants from the UK Biobank, researchers built multi-omics clocks to measure the aging…
Physical performance predicts fracture risk in older adults
In older men, a five-variable physical model beat FRAX without bone scans, raising 10-year fracture discrimination by an area under the curve of…In older men, a five-variable physical model beat FRAX without bone scans, raising 10-year fracture discrimination by an area under the curve of 0.052. In community-dwelling older men and women, researchers evaluated whether an imaging-free model based on physical performance could predict…
Electrocardiogram heart age reflects past electrical burden but not future aging pace
Researchers analyzed serial electrocardiograms from over 128,000 patients to distinguish cumulative cardiac aging damage from the rate of future…Researchers analyzed serial electrocardiograms from over 128,000 patients to distinguish cumulative cardiac aging damage from the rate of future electrical changes. In an observational study of 128,605 human patients, researchers analyzed 399,786 standard 12-lead electrocardiograms to…
Speech age gaps track dementia phenotypes and biological aging
In 2,928 individuals across five Latin American countries, speech age gaps tracked dementia diagnoses, brain age, social exposome, and epigenetic…In 2,928 individuals across five Latin American countries, speech age gaps tracked dementia diagnoses, brain age, social exposome, and epigenetic aging clocks. In a cross-sectional study of 2,928 human participants across five Latin American countries, researchers developed a speech-based…
Linguistic features from recall tests detect cognitive impairment
In 710 older adults, delayed recall linguistic scores predicted cognitive impairment with an AUC-PR of 0.77, compared with 0.81 for traditional…In 710 older adults, delayed recall linguistic scores predicted cognitive impairment with an AUC-PR of 0.77, compared with 0.81 for traditional scoring. In 710 older adults from the Long Life Family Study, researchers analyzed digital voice recordings from logical memory tests.
Association Between Nutritional Status and Severe Sarcopenia in Maintenance Hemodialysis Patients: A Multicenter Cross-Sectional Study with Diagnostic Model Development
Wed 30 Sep21 papers
Normative brain models reveal dopamine shifts in early amyloid
In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status…In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted difference of −0.582.
DECIPHER decodes cell types and predicts age from bulk omics
Tested across multiple molecular platforms, the framework separates technical variation from biological signal to infer cell proportions and…Tested across multiple molecular platforms, the framework separates technical variation from biological signal to infer cell proportions and chronological age across independent human cohorts.
Blood and facial photos track organ aging and senescence scores in humans
Researchers used transcriptomic models, DNA methylation, and images across multiple human cohorts to infer tissue-specific biological age and hallmark…Researchers used transcriptomic models, DNA methylation, and images across multiple human cohorts to infer tissue-specific biological age and hallmark burdens. In a preprint analyzing human datasets, researchers developed transcriptomic clocks to infer organ biological age and cellular…
Model predicts functional and financial vulnerability in older adults
Penalized regression achieved an AUROC of 0.728 for dual vulnerability and 0.755 for death, against 0.629 for catastrophic health spending alone.Penalized regression achieved an AUROC of 0.728 for dual vulnerability and 0.755 for death, against 0.629 for catastrophic health spending alone. In older Chinese adults, researchers evaluated transitions between functional impairment, catastrophic health spending, and death.
Machine learning flags sleep disorders in postmenopausal women
In 2,397 postmenopausal women, sleep disorder prevalence reached 62.4%, with depressive status showing the strongest association at an odds ratio of…In 2,397 postmenopausal women, sleep disorder prevalence reached 62.4%, with depressive status showing the strongest association at an odds ratio of 4.067. In a cross-sectional study of 2,397 naturally postmenopausal women aged 45 to 60 years from China, researchers evaluated machine…
[Development of a machine learning-based model for assessing pulmonary function in elderly patients]
Comprehensive exposome score predicts incident dementia risk
An exposome-based model reached an AUC of 0.718 for incident dementia, outperforming demographics and APOE status alone at 0.678 over 15.3 years of…An exposome-based model reached an AUC of 0.718 for incident dementia, outperforming demographics and APOE status alone at 0.678 over 15.3 years of follow-up. Researchers analyzed 499,992 UK Biobank participants aged 40 to 69 to evaluate how 193 environmental factors across five domains…
Human vellus hair units undergo cellular and metabolic remodeling during skin aging
A single-nucleus atlas reveals stem cell loss, altered sebocyte activity, and shifted immune interactions in the hair follicles of older men.A single-nucleus atlas reveals stem cell loss, altered sebocyte activity, and shifted immune interactions in the hair follicles of older men. In a study of healthy young and aged human males, researchers constructed a single-nucleus transcriptomic atlas of vellus hair pilosebaceous units…
AI lung scan score links to fibrosis progression and mortality
A baseline deep learning score above 0.5 was associated with a 13.41% relative annual fibrosis increase and higher mortality in two human cohorts.A baseline deep learning score above 0.5 was associated with a 13.41% relative annual fibrosis increase and higher mortality in two human cohorts. In human participants without clinically diagnosed interstitial lung disease, automated CT scan analysis identified individuals at elevated…
Human abdominal organ volumes peak in midlife then decline
In 15,408 adult patients, automated CT analysis showed liver, pancreas, and kidney volumes peaked in midlife before declining, while tissue…In 15,408 adult patients, automated CT analysis showed liver, pancreas, and kidney volumes peaked in midlife before declining, while tissue attenuation generally dropped with age.
Analysis of Dietary Patterns Containing Curcumin and Oral Cancer
Sex-specific shape models to disentangle sex effects and age-associated anatomical variation in biventricular cardiac anatomy
