Modelling and theory
Method75 papers
- Human trial1
- Humans23
- Animals1
- Model organisms1
- In silico28
Latest
75Exercise, Glucose and Lactate Metabolism in Mild Cognitive Impairment: A Narrative Review
Forecasting global progress towards the United Nations hypertension control target for 2030
Tool converts plasma pTau217 values across testing platforms
Assays predicted amyloid-beta positivity with AUCs of 0.929 to 0.952, while simulated pTau217 screening cut amyloid PET scans by over 60%.Assays predicted amyloid-beta positivity with AUCs of 0.929 to 0.952, while simulated pTau217 screening cut amyloid PET scans by over 60%.
Summary-level genetic method improves Alzheimer's risk prediction
The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve…The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve Alzheimer's disease risk prediction.
Age and frailty interaction models predict hip fracture mortality
Across 115,643 patients, predicted 30-day mortality ranged from 0.48% to 32.06% depending on age, frailty, and surgical fixation type.Across 115,643 patients, predicted 30-day mortality ranged from 0.48% to 32.06% depending on age, frailty, and surgical fixation type.
Model-based evaluation of an infant HPV prophylactic vaccination program in Nigeria
Cost-Effectiveness of AI in Breast Cancer Screening and Lung Cancer Diagnostics: A Case Study From Costa Rica
Deciphering the gene-centric spatial dynamics across tissue and time with GeneSPOT
Stress and recovery dynamics reveal transcriptomic stability limits across aging mouse organs
Researchers used sleep deprivation and neural ordinary differential equations to track organ gene expression shifts and recovery boundaries in young…Researchers used sleep deprivation and neural ordinary differential equations to track organ gene expression shifts and recovery boundaries in young and aged mice.
Mechanistic biological age clock matches PhenoAge in predicting human mortality
The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to…The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.
Blood methylation framework maps dependencies between aging hallmarks and organ aging
A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand…A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand participants.