Navitoclax
InterventionSenolytics2 papers1 findingPubChem 24978538
- Model organisms1
- Cells1
Outcomes
1Senescent cell
downin zebrafish1
1 study
Senescent cell
downin zebrafish1
Navitoclax decreases senescent cell in zebrafish.
Animalsin cells with high UHRF1 levelshepatocyte
UHRF1 levels drive distinct senescent states in zebrafish liver cells · EMBO reports · 28 Sep 2026
Latest
2Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
Neoplasia (New York, N.Y.) · Lin C et al.
UHRF1 levels drive distinct senescent states in zebrafish liver cells
High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated.
EMBO reports · Magnani E et al.