Estrogen
Intervention4 papers3 findingsPubChem 21628493
- Humans3
- Animals1
Outcomes
2Trabecular bone microarchitecture
upin rats1Very low certainty
1 study
Trabecular bone microarchitecture
upin rats1Very low certainty
Estrogen improves trabecular bone microarchitecture in rats.
“improved trabecular bone microarchitecture”
Animalsin ovariectomized rats
Estrogen Suppresses Osteoclast Function and Cytoskeletal Remodeling via Modulation of the RhoA-Pkn3-c-Src Signaling Pathway in Ovariectomized Rats · Biology · 9 Sep 2026
Bone loss
downin rats1Very low certainty
1 study
Bone loss
downin rats1Very low certainty
Estrogen decreases bone loss in rats.
“Estrogen treatment markedly alleviated OVX-induced bone loss”
Animalsin ovariectomized rats
Estrogen Suppresses Osteoclast Function and Cytoskeletal Remodeling via Modulation of the RhoA-Pkn3-c-Src Signaling Pathway in Ovariectomized Rats · Biology · 9 Sep 2026
Associations
1Urinary lactobacilli
upin humans1Very low certainty
1 study
Urinary lactobacilli
upin humans1Very low certainty
Estrogen is associated with urinary lactobacilli in humans.
Humansin postmenopausal womenvaginalat least 6 weeksfemales
Vaginal estrogen is linked to premenopausal-like urinary microbes · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint
Latest
30TRPM3 inhibition reverses depressive behaviors in rats
In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and…In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and depressive-like deficits.
Estrogen-responsive variants interact with reproductive risk factors
In 13,026 post-menopausal cases and 108,265 controls, an estrogen-responsive polygenic score interacted with reproductive traits including age at…In 13,026 post-menopausal cases and 108,265 controls, an estrogen-responsive polygenic score interacted with reproductive traits including age at first birth (p=0.0052).
Vaginal estrogen is linked to premenopausal-like urinary microbes
In a preprint comparing women across menopausal stages, at least six weeks of vaginal estrogen tracked with more lactobacilli and fewer opportunistic…In a preprint comparing women across menopausal stages, at least six weeks of vaginal estrogen tracked with more lactobacilli and fewer opportunistic pathogens.
Tamoxifen causes temporary ovarian disruption without altering long-term mouse aging trajectories
A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.