Liver steatosis

1. Nicotinamide riboside + magnesium-l-theanine decreases liver steatosis in rats.

   “Histological analysis confirmed amelioration of CVS-induced liver steatosis and intestinal architectural damage.”

   Animalschronic variable stressliver40 days

   Combined nicotinamide riboside and magnesium-l-theanine protects against chronic stress-induced gut-liver injury by modulating NAD⁺ and metabolic pathways

   Molecular biology reports·3 Oct 2025

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1. Environmental enrichment decreases liver steatosis in mice.

   “EE decreased age-related liver steatosis”

   Animalsliver

   Implementation of environmental enrichment after middle age promotes healthy aging

   Aging·20 Jul 2018

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1. SRT1720 decreases liver steatosis in mice.

   “lifespan extension is accompanied by health benefits including reduced liver steatosis”

   Animalsin mice fed a high-fat diet

   SRT1720 improves survival and healthspan of obese mice

   Scientific reports·18 Aug 2011

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1. Resveratrol decreases liver steatosis in mice.

   “resveratrol reversed liver steatosis, lipid peroxidaton, and the defenestration phenotypes observed in such mice.”

   Animalsin Wrn mutant miceliver

   Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome

   The journals of gerontology. Series A, Biological sciences and medical sciences·25 Oct 2010

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1. FDXR protects against liver steatosis in mice.

   “and liver steatosis”

   Animalsshown by Fdxr+/- and Trp53+/- mice

   Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1-SREBP pathway

   Oncogene·4 Feb 2022

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1. MAP3K8 protects against liver steatosis in mice.

   “male Tpl2-KD mice had higher bodyweight and an increased incidence of liver steatosis”

   Animalsloss of Tpl2 kinase activitylivermales

   Tpl2 kinase regulates inflammation but not tumorigenesis in mice

   Toxicology and applied pharmacology·13 Mar 2021

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1. ITPR2 increases liver steatosis in mice.

   “less liver steatosis and fibrosis”

   Animalsknockoutliver

   Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

   Nature communications·1 Feb 2021

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1. RBM38 increases liver steatosis in mice.

   “loss-of-Rbm38 markedly decreased the percentage of liver steatosis in TAp63+/- mice”

   Animalsin TAp63+/- miceliver

   The Rbm38-p63 feedback loop is critical for tumor suppression and longevity

   Oncogene·9 Mar 2018

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1. RBM38 raises the risk of liver steatosis in mice.

   “S193D KI mice have a shortened life span and are prone to spontaneous tumors, chronic inflammation, and liver steatosis”

   AnimalsS193D knock-in

   Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38

   Genes & development·4 Mar 2021

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