RBM38

3 papers9 findings

HGNC NCBI Gene Taxon

1 lab in 1 country
1 finding against

Funders: Division of Cancer Prevention, National Cancer Institute and 3 more

Animals3

Effects

5

Cellular senescence

upin mice1upin mouse cells1

2 studies

RBM38 increases cellular senescence in mice.
“S193D KI enhances p53-dependent cellular senescence”
AnimalsS193D knock-in
Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38
Genes & development4 Mar 2021
RBM38 increases cellular senescence in mouse cells.
“Rbm38-/-;TAp63+/- MEFs were resistant, whereas Rbm38-/- or TAp63+/- MEFs were prone, to cellular senescence”
Cellsin TAp63+/- mice
The Rbm38-p63 feedback loop is critical for tumor suppression and longevity
Oncogene9 Mar 2018

More on Cellular senescence

Inflammation

upin mice1

1 study

RBM38 increases inflammation in mice.
“S193D KI mice have a shortened life span and are prone to spontaneous tumors, chronic inflammation, and liver steatosis”
AnimalsS193D knock-in
Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38
Genes & development4 Mar 2021

More on Inflammation

Lifespan

downin mice1

1 study

RBM38 shortens lifespan in mice.
“S193D KI mice have a shortened life span”
AnimalsS193D knock-in
Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38
Genes & development4 Mar 2021

Liver steatosis

upin mice1

1 study

RBM38 increases liver steatosis in mice.
“loss-of-Rbm38 markedly decreased the percentage of liver steatosis in TAp63+/- mice”
Animalsin TAp63+/- miceliver
The Rbm38-p63 feedback loop is critical for tumor suppression and longevity
Oncogene9 Mar 2018

More on Liver steatosis

Accelerated aging

downin mice1

1 study

RBM38 decreases accelerated aging in mice.
“mice deficient in Rbm38 exhibit signs of accelerated aging”
Animalsshown by knockout
Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors
Proceedings of the National Academy of Sciences of the United States of America15 Dec 2014

Associations

2

Spontaneous tumors

upin mice1downin mice1

2 studies

RBM38 raises the risk of spontaneous tumors in mice.
“S193D KI mice have a shortened life span and are prone to spontaneous tumors, chronic inflammation, and liver steatosis”
AnimalsS193D knock-in
Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38
Genes & development4 Mar 2021
RBM38 lowers the risk of spontaneous tumors in mice.
“Rbm38 is necessary for normal hematopoiesis and for suppressing accelerated aging and tumorigenesis”
Animalsshown by knockout
Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors
Proceedings of the National Academy of Sciences of the United States of America15 Dec 2014

More on Spontaneous tumors

Liver steatosis

upin mice1

1 study

RBM38 raises the risk of liver steatosis in mice.
“S193D KI mice have a shortened life span and are prone to spontaneous tumors, chronic inflammation, and liver steatosis”
AnimalsS193D knock-in
Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38
Genes & development4 Mar 2021

More on Liver steatosis

Latest

Genes & Development4 Mar

Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38

Experiments in miceMechanisms

Oncogene9 Mar

The Rbm38-p63 feedback loop is critical for tumor suppression and longevity

Experiments in miceMechanisms

PNAS15 Dec

Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors

Experiments in miceTP53