Mild cognitive impairment or dementia
4 papers8 findings
- Humans3
Associations
8Amyloid and tau pathology
upin humans1
1 study
Amyloid and tau pathology
upin humans1
Amyloid and tau pathology predicts mild cognitive impairment or dementia in humans (>50%).
“>50% of CU with high amyloid and tau progress to MCI/dementia within 5 years”
Reviewcognitively unimpaired individuals with high amyloid and tau5 years
Alzheimer's Disease Begins Years Before Symptoms: Alzheimer's Association Workgroup
AAIC 2025 abstract9 Jan 2026
Neuropsychiatric symptoms
upin humans1
1 study
Neuropsychiatric symptoms
upin humans1
Neuropsychiatric symptoms raise the risk of mild cognitive impairment or dementia in humans (3x higher odds).
“The High‐All group had the greatest progression risk to MCI/dementia, with 3x higher odds than Low‐All ( p < .001)”
Humans
AAIC 2025 abstract24 Dec 2025
Subtle objectively-defined cognitive impairment and subjective cognitive decline
upin humans1
1 study
Subtle objectively-defined cognitive impairment and subjective cognitive decline
upin humans1
Subtle objectively-defined cognitive impairment and subjective cognitive decline raises the risk of mild cognitive impairment or dementia in humans.
“Participants with both sOCI and SCD had the highest risk of progression to MCI or dementia.”
Humansbaseline free from MCI or dementia
Subtle Objective and Subjective Cognitive Decline Predict Risk of Dementia
AAIC 2025 abstract24 Dec 2025
More on Subtle objectively-defined cognitive impairment and subjective cognitive decline
Self-reported subjective cognitive decline
upin humans1HR 1.85
1 study
Self-reported subjective cognitive decline
upin humans1HR 1.85
Self-reported subjective cognitive decline predicts mild cognitive impairment or dementia in humans (HR=1.85, p = 0.04).
“and self‐reported SCD (HR=1.85, p = 0.04)”
Humansbaseline free from MCI or dementia
Subtle Objective and Subjective Cognitive Decline Predict Risk of Dementia
AAIC 2025 abstract24 Dec 2025
Subtle objectively-defined cognitive impairment
upin humans1HR 2.61
1 study
Subtle objectively-defined cognitive impairment
upin humans1HR 2.61
Subtle objectively-defined cognitive impairment predicts mild cognitive impairment or dementia in humans (HR=2.61, p = 0.02).
“followed by sOCI (HR=2.61, p = 0.02)”
Humansbaseline free from MCI or dementia
Subtle Objective and Subjective Cognitive Decline Predict Risk of Dementia
AAIC 2025 abstract24 Dec 2025
Informant-reported subjective cognitive decline
upin humans1HR 2.97
1 study
Informant-reported subjective cognitive decline
upin humans1HR 2.97
Informant-reported subjective cognitive decline predicts mild cognitive impairment or dementia in humans (HR=2.97, p <0.0001).
“Informant‐reported SCD had the highest OR for prediction of future MCI/dementia (HR=2.97, p <0.0001)”
Humansbaseline free from MCI or dementia
Subtle Objective and Subjective Cognitive Decline Predict Risk of Dementia
AAIC 2025 abstract24 Dec 2025
Amyloid PET positivity
upin humans1
1 study
Amyloid PET positivity
upin humans1
Amyloid PET positivity raises the risk of mild cognitive impairment or dementia in humans (from 9.09% to 42.42%).
“percentage of progressors in the A+T‐ group increased from 9.09% to 42.42%”
Humans
The clinical prognosis of cognitively unimpaired individuals with positive PET biomarkers
AAIC 2025 abstract24 Dec 2025
Amyloid and tau PET positivity
upin humans1+100%
1 study
Amyloid and tau PET positivity
upin humans1+100%
Amyloid and tau PET positivity raises the risk of mild cognitive impairment or dementia in humans (100%).
“100% of the PREVENT‐AD participants who were A+T+ have now progressed to MCI or dementia”
Humans
The clinical prognosis of cognitively unimpaired individuals with positive PET biomarkers
AAIC 2025 abstract24 Dec 2025