ITPR2

1. ITPR2 mediates cellular senescence in mice.

   “IP3R2-mediated cellular senescence”

   Animalsin CVB3-induced acute viral myocarditis

   1,25-dihydroxyvitamin D deficiency accelerates inflammatory response by up-regulating inositol 1,4,5-triphosphate receptor in Coxsackievirus B3-induced acute myocarditis

   International immunopharmacology·20 Jul 2025

2. ITPR2 induces cellular senescence in mice.

   “Cellular senescence, which is known to promote these alterations, is decreased in Itpr2 KO mice”

   Animalsknockout

   Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

   Nature communications·1 Feb 2021

More on Cellular senescence

1. ITPR2 increases mitochondria-ER contacts in mice.

   “ablation of ITPR2 in vivo and in vitro decreases the number of contacts between the mitochondria and the ER”

   Animalsin vivo and in vitro ablation

   Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

   Nature communications·1 Feb 2021

1. ITPR2 increases fibrosis in mice.

   “less liver steatosis and fibrosis”

   Animalsknockoutliver

   Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

   Nature communications·1 Feb 2021

1. ITPR2 increases liver steatosis in mice.

   “less liver steatosis and fibrosis”

   Animalsknockoutliver

   Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

   Nature communications·1 Feb 2021

More on Liver steatosis

1. ITPR2 shortens lifespan in mice.

   “Itpr2 knockout (KO) mice display improved aging such as increased lifespan”

   Animalsknockout

   Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

   Nature communications·1 Feb 2021