AgingResearch.NewsJoin free

MAP3K8

Gene

2 papers2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 2 of 2 findings with company ties
  • Humans1
  • Animals1

Effects

2

Liver steatosis

downin mice1

1 study

  1. MAP3K8 protects against liver steatosis in mice.

    “male Tpl2-KD mice had higher bodyweight and an increased incidence of liver steatosis”

    Animalsloss of Tpl2 kinase activitylivermales

    Tpl2 kinase regulates inflammation but not tumorigenesis in mice

    Toxicology and applied pharmacology13 Mar 2021

More on Liver steatosis

Spontaneous tumors

no changein mice1

1 study

  1. MAP3K8 has no effect on spontaneous tumors in mice.

    “incidence and severity of spontaneous tumors and non-neoplastic lesions were comparable between wild type and Tpl2-KD mice”

    Animalskinase-dead mutation

    Tpl2 kinase regulates inflammation but not tumorigenesis in mice

    Toxicology and applied pharmacology13 Mar 2021

More on Spontaneous tumors

Latest

Related