Papers on disequilibrium

206 papers19 new in 30 days

Tuesday, October 27

Scientific ReportsOct 27

Genetic and expression evidence supports FTO rs9939609 as a key susceptibility marker for type 2 diabetes and obesity in Thai adults

Cross-sectional study of 798 peopleObesity

Paper

BiomedicinesOct 27

Genetically Predicted Circulating Lipid Traits and Risk of Primary Open-Angle Glaucoma: A Mendelian Randomization Study

Flowchart of the study design and two-sample Mendelian randomization pipeline.

Mendelian randomization in peopleEye

Paper

GenesOct 27

Hypoglycemic Agent Targets and Susceptibility to Lower Respiratory Infection: A Pharmacogenomic Mendelian Randomization Study

Study design and analytical workflow for drug-target Mendelian randomization.

Mendelian randomization in peopleLower respiratory tract infection

Paper

Monday, October 26

ESC Congress 2026 AbstractOct 26

Measures of cardiovascular aging share little genetic overlap

In 163,721 UK Biobank participants, computer models of four cardiovascular aging tests showed distinct patterns with low genetic correlation across heart, artery, and eye…In 163,721 UK Biobank participants, computer models of four cardiovascular aging tests showed distinct patterns with low genetic correlation across heart, artery, and eye scans.

A heart cross-section shows broad muscle bands and dark conduction branches beneath a forked artery and a retina with fine branching vessels.

Genetic association · 163,721 peopleBiomarkers

Paper

ESC Congress 2026 AbstractOct 26

Bidirectional mendelian randomzation study of TET2-clonal haematopoiesis of indeterminate potential-mutations with hs-CRP in patients with STEMI

Mendelian randomization in peopleTET2

Paper

Monday, October 19

Genome MedicineOct 19

Genetic scores better predict coronary artery disease in China

In training, a statistical performance measure rose approximately 60% versus the best East Asian-specific score and 90% versus the best European-specific score.In training, a statistical performance measure rose approximately 60% versus the best East Asian-specific score and 90% versus the best European-specific score.

Case-control studyCoronary artery disease

Paper

Annals of EpidemiologyOct 19

Network Analysis of Chronic Disease Diagnosis Co-documentation in Insurance Claims Among Older Arkansans

Cross-sectional study of 35,253 peoplePopulations

Paper

Sunday, October 18

IMetaOmicsOct 18

Move beyond free radical theory of aging

ReviewMechanisms

Paper

Saturday, October 17

MedicineOct 17

The bidirectional causal relationships of insomnia with eleven cancers: A Mendelian randomization study

The study design of the Mendelian randomization analysis on the causal associations between insomnia and eleven cancers.

Mendelian randomization in peopleInsomnia

Paper

Friday, October 16

Journal of the American Heart AssociationOct 16

Genetic analysis links shared DNA signals to artery disease

An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritized candidate protein targets.An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritized candidate protein targets.

Genetic association studyMechanisms

Paper

Thursday, October 15

Journal of Alzheimer's Disease ReportsOct 15

Two blood fats linked to lower Alzheimer's disease risk

An analysis of human genetic data suggested that other blood-fat measures may partly account for the associations with Alzheimer's disease.An analysis of human genetic data suggested that other blood-fat measures may partly account for the associations with Alzheimer's disease.

Overview of the Mendelian randomization study design.

Mendelian randomizationMechanisms

Paper

Tuesday, October 13

Frontiers in Aging NeuroscienceOct 13

Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?

Microglial metabolic programming by lysosome-mediated lipid homeostasis and flux.

ReviewAutophagy

Paper

Monday, October 12

Translational PsychiatryOct 12

Genetic risk and lifestyle linked to estimated brain aging

An observational study of 46,843 UK Biobank participants linked higher genetic risk and unhealthy lifestyles to faster aging estimated from brain scans.An observational study of 46,843 UK Biobank participants linked higher genetic risk and unhealthy lifestyles to faster aging estimated from brain scans.

Cohort study of 46,843 peopleBiomarkers

Paper

Sunday, October 11

medRxivOct 11

Retinal arteriolar tortuosity as a candidate genetic window to inner-ear microvasculature: distributed sharing with blood pressure at CSK and PAWR and a roadmap for larger hearing GWAS

Study design and overall analytical framework.

Preprint: genetic association study in peopleSystolic blood pressure

Paper

Friday, October 9

MedicineOct 9

Shared genetic architecture between constipation and aging-related phenotypes: Insights from large-scale genome-wide cross-trait analysis

The Shared Genetic Atlas of Constipation and Aging Phenotypes.

Computational studyMechanisms

Paper

Tuesday, October 6

Functional & Integrative GenomicsOct 6

Blood taurine linked to common and rare DNA variants

An analysis of 36,490 European individuals identified six regions with common DNA variants and two with rare variants associated with blood taurine levels.An analysis of 36,490 European individuals identified six regions with common DNA variants and two with rare variants associated with blood taurine levels.

Study of 36,490 peopleMechanisms

Paper

Friday, October 2

MedicineOct 2

Sex hormone-binding globulin raises lumbar fracture risk

Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone density.Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone density.

Study flow chart. ① IVs must be strongly associated with the exposures (SHBG and candidate mediators).

Mendelian randomization in peopleBones and joints

Paper

Genetics in Medicine OpenOct 2

Population-specific optimization of polygenic risk scores for breast cancer in East Asians

Workflow for PRS development and SNP substitution strategy, with Venn diagram visualization of SNP distribution patterns across sample cohorts.

Cohort study of 46,422 peopleBreast cancer

Paper

Tuesday, September 29

Molecular Genetics and GenomicsSep 29

Higher CALLY index is causally linked to lower dementia risk

Mendelian randomization across more than 265,000 UK Biobank and FinnGen participants linked a higher CALLY score to reduced dementia risk but increased sleep disorder…Mendelian randomization across more than 265,000 UK Biobank and FinnGen participants linked a higher CALLY score to reduced dementia risk but increased sleep disorder risk.