Genes
Shared Genetic Architecture Between Epigenetic Aging and Musculoskeletal Diseases
Mendelian randomization in 788 peopleMusculoskeletal disease
Papers on disequilibrium
214 papers18 new in 30 days
Thursday, August 27
Ageing & Longevity
Human Longevity and Immunogenetic Architecture: A Biogerontological Perspective
ReviewMechanisms
Thursday, August 20
Monday, August 17
medRxiv
Additive Multilocus Burden and Epistatic Interactions Improves Genetic Risk Predictions for Complex Diseases
Preprint: cohort study of 235,000 peopleBiomarkers
Friday, August 7
Research Square
Common variants in the lysosomal pathway contribute to Parkinson's Disease risk
Preprint: cohort study of 7,668 peopleParkinson's disease
Monday, August 3
medRxiv
Dissecting the Genetic Link Between Insulin Resistance and Coronary Heart Disease: A Multi-Trait GWAS and Proteomic-Metabolomic Mediation Analysis
Preprint: cohort study of 407,767 peopleLipid and ceramide metabolism
Friday, July 31
medRxiv
Genetic susceptibility and causes for early-onset breast cancer: insights from genome-wide and phenome-wide analyses
Preprint: genetic association study of 280,863 peopleBreast cancer
Saturday, July 25
American Journal of Human Genetics
Allele frequency trajectories across age groups reveal ongoing natural selection shaping disease susceptibility
Genetic association study of 72,635 peopleMechanisms
Saturday, July 18
Medicine
Exploring the cognitive effects of arthritis: A Mendelian randomization study and cross-sectional analysis of NHANES data
Mendelian randomization in 1,569 peopleMechanisms
Friday, July 17
PLOS One
Do common dopaminergic variants modulate processing speed in cognitive aging? A longitudinal candidate gene study
Cohort study of 1,539 peopleMechanisms
Cell Reports Medicine
Functional matrix vesicle replacement partially restores chemo-mechanical coupling in the aged bone niche
Experiments in miceBones and joints
Thursday, July 16
Wednesday, July 15
Dermatological Reviews
The Hammock Hypothesis: An Integrative Conceptual Framework for Facial Aging
ReviewMechanisms
Saturday, July 11
Tuesday, July 7
bioRxiv
TrustPGS: When can a polygenic score be trusted? A per-individual reliability framework across ancestries
Preprint: computational studyBiomarkers
Wednesday, July 1
Food Frontiers
Genetic Evidence From Linkage Disequilibrium Score Regression and Mendelian Randomization Links Cheese Intake to Cognitive Function
Mendelian randomization in peoplePopulations
Tuesday, June 30
ACR Open Rheumatology
Exploring the Shared Genetic Basis of Age at Menopause and Osteoarthritis
Computational studyBones and joints
Precision and Future Medicine
Causal associations between osteosarcopenia-related traits and degenerative spinal disorders: a bidirectional Mendelian randomization study
Mendelian randomization in peopleOsteosarcopenia
Friday, June 26
Saturday, June 6
ADA Scientific Sessions 2026 Abstract
Genetic Variation in GUSB Is Associated with Circulating ß-Glucuronidase and Metabolic Traits in Hispanic Postmenopausal Women
Genetic association study of 214 peopleMechanisms
Sunday, May 31
Communications Medicine
Proxied therapeutic inhibition on sclerostin and atrial fibrillation risk
Mendelian randomization in peopleMechanisms
Monday, May 4
Wednesday, April 29
medRxiv
A shared MHC immunogenetic signal connects aging, rheumatoid arthritis, and herpes zoster through chronic high inflammatory burden–compensatory immune tolerance dysregulation
Preprint: Mendelian randomization in peopleImmune response
Monday, April 20
medRxiv
Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries
Preprint: computational studyKidney
Sunday, April 12
BMC Genomics
Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel
Experiments in miceMechanisms
Wednesday, April 8
bioRxiv
Drosophila pseudoobscura third chromosome inversion arrangements have temperature-dependent and sex-specific effects on life history traits
Preprint: experiments in model organismsMechanisms
Tuesday, March 31
Research Square
Replication of association of ENPP1 polymorphisms and haplotypes with severe obesity in a Greek study population
Preprint: case-control study of 979 peopleSevere obesity
Tuesday, March 24
Calcified Tissue International
Advanced Bayesian BMD-Derived Genome-Wide Polygenic Scores Enhance Clinical FRAX-Based Fracture Risk Prediction in Postmenopausal Women
Cohort study of 6,932 peopleFRAX
Saturday, March 21
Preprints.org
Loss of Proteostasis and Abnormal Aging in Down Syndrome: From Mechanisms to Interventions
Preprint: reviewProteostasis
Friday, March 20
International Journal of Chronic Obstructive Pulmonary Disease
Genetic Architecture of Comorbidity Between Chronic Obstructive Pulmonary Disease and Cardiovascular Diseases: Exploring Shared Mechanisms and Potential Therapeutic Targets
Computational studyLung