In 163,721 UK Biobank participants, computer models of four cardiovascular aging tests showed distinct patterns with low genetic correlation across heart, artery, and eye…In 163,721 UK Biobank participants, computer models of four cardiovascular aging tests showed distinct patterns with low genetic correlation across heart, artery, and eye scans.
In training, a statistical performance measure rose approximately 60% versus the best East Asian-specific score and 90% versus the best European-specific score.In training, a statistical performance measure rose approximately 60% versus the best East Asian-specific score and 90% versus the best European-specific score.
Who was studiedChinese coronary artery disease cases and controls
What changedIn the Chinese training group, combined-ancestry scores improved model fit by approximately 60% against the best East Asian-specific scores
The catchThe improvement measures training-set model fit, a stand-in for prediction in new patients
An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritized candidate protein targets.An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritized candidate protein targets.