Steatotic liver disease
Disease1 paper
- Humans1
Trial sponsors
Resolution Therapeutics Limited
1 trialPhase 1/230 people
Latest
32Three-protein combination eased chronic liver disease in rats
In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased…In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival.
Innovative holistic treatment for CKM: what lies ahead?
A 5:2 fasting regimen curbs muscle impairment in mice
Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without…Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without altering cumulative energy intake.
Cardiometabolic burden is linked to CVD and death in MASLD
In 72,922 adults with MASLD, each extra risk factor carried a hazard ratio of 1.17 for incident CVD and 1.09 for direct death.In 72,922 adults with MASLD, each extra risk factor carried a hazard ratio of 1.17 for incident CVD and 1.09 for direct death.
NMR metabolomics improves prediction of cardiometabolic diseases
In 54,933 healthcare system participants, profiling 250 NMR biomarkers enhanced standard risk prediction for type 2 diabetes, kidney disease, and…In 54,933 healthcare system participants, profiling 250 NMR biomarkers enhanced standard risk prediction for type 2 diabetes, kidney disease, and liver disease.
Weight gain, adipose tissue remodeling and cardiometabolic disease in people with HIV
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with…Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.