Papers on brain aging

3,754 papers124 new in 30 days

Thursday, October 22

Neurobiology of StressOct 22

Associations of post-traumatic stress disorder and metabolic syndrome with accelerated brain aging in South African adults: A case-control study

Flow chart illustrating participant selection procedures used to include suitable cases and controls.

Case-control study of 97 peoplePost-traumatic stress disorder

Paper

Wednesday, October 21

Kardiovaskulyarnaya Terapiya I ProfilaktikaOct 21

Mechanisms of brain aging. A review: Part I

ReviewMechanisms

Paper

bioRxivOct 21

Cell identity stayed intact in aging mouse brain cells

An animal study of the mouse hippocampus found cell-specific changes in DNA marks while the basic patterns of gene regulation remained intact.An animal study of the mouse hippocampus found cell-specific changes in DNA marks while the basic patterns of gene regulation remained intact.

DNA Modification patterns across microglia, neurons, and astrocytes.

Preprint: mouse studyMechanisms

Paper

arXivOct 21

Brain scan model improved the accuracy of brain age predictions

Pretrained on 74,425 brain MRI scans, Brain2Vec predicted brain age more accurately and learned faster than a model starting from random settings.Pretrained on 74,425 brain MRI scans, Brain2Vec predicted brain age more accurately and learned faster than a model starting from random settings.

A large brain cross-section has offset pale folds on one side and closely fitted dark folds on the other, surrounded by smaller brain sections.

Preprint: computational studyAI & data

Paper

Tuesday, October 20

medRxivOct 20

APOE ε4 Modifies the Association of Left Atrial Remodeling With Brain Aging

Preprint: cohort study of 1,305 peoplePopulations

Paper

Monday, October 19

The Journals of Gerontology, Series AOct 19

Abdominal ultrasound mitigates neurodegenerative pathology and alters specific gut microbial taxa in senescence-accelerated mice

Experiments in miceInterventions

Paper

Sunday, October 18

bioRxivOct 18

Female mouse brains extracted a smaller share of blood oxygen

In a laboratory experiment, 15-month-old female mice had higher blood flow in the brain’s outer layer than males, without a deficit in oxygen delivery through arteries.In a laboratory experiment, 15-month-old female mice had higher blood flow in the brain’s outer layer than males, without a deficit in oxygen delivery through arteries.

Sex-dependent changes in CBF and brain volumetrics.

Preprint: mouse study · 12 miceMechanisms

Paper

Journal of Psychiatric ResearchOct 18

No effect of transcranial direct current stimulation on brain age during cognitive behavioral therapy for major depressive disorder: secondary results from a randomized, double-blind, sham-controlled trial

Figure from Journal of Psychiatric Research

Randomized trial in 38 peopleTranscranial direct current stimulation

Paper

Alzheimer's & DementiaOct 18

Brain scans and blood markers may help detect thinking problems

In an observational study of 1,297 people without dementia, combined brain and blood measures showed the strongest links to disease progression.In an observational study of 1,297 people without dementia, combined brain and blood measures showed the strongest links to disease progression.

Summary of relationships between chronological age and Spatial Pattern of Atrophy for Recognition of Brain Aging (SPARE‐BA) and Spatial Pattern of Atrophy for Recognition of Alzheimer's Disease…

Cohort · 1,297 peopleBiomarkers

Paper

Frontiers in NutritionOct 18

Influence of Curcuma longa extract on cognitive function in mild cognitive impairment due to Alzheimer's disease: a single-arm, open-label, observational study

Box-and-whisker plots and spaghetti plots of cognitive function measures from baseline (0 M) to month 4 (4 M) during the observation period.

Non-randomized trial in 10 peopleMild cognitive impairment

Paper

Saturday, October 17

Nature Reviews NeuroscienceOct 17

The endocannabinoid system and the ageing brain

ReviewMechanisms

Paper

Neurotoxicology and TeratologyOct 17

Differential sensitivity of MRI-based brain-age models to chronic noise exposure: an exploratory comparative study

Figure from Neurotoxicology and Teratology

Cross-sectional study of 108 peoplePopulations

Paper

Friday, October 16

Molecular NeurobiologyOct 16

Caffeine and Exercise in Obesity-Associated Brain Aging and Neurodegeneration: Mechanistic Insights into AMPK/SIRT1/PGC-1α, BDNF/TrkB, and NLRP3 Inflammasome Signaling

ReviewCaffeine

Paper

NutrientsOct 16

Do Grape- and Wine-Derived (Poly)Phenols Contribute to the Hallmarks of Healthy Brain Ageing?

Ageing-related gut-brain axis dysregulation and brain health decline.

ReviewInterventions

Paper

Handbook of Clinical NeurologyOct 16

Epigenetic mechanisms in brain aging and their role in cognitive decline and mental health disorders

ReviewMechanisms

Paper

Neuroscience and Biobehavioral ReviewsOct 16

From Gut Microbiome to Aging Brain: Butyrate as a Neurogeroscience Effector

Figure from Neuroscience and Biobehavioral Reviews

ReviewMicrobiome composition

Paper

Progress in Neuro-psychopharmacology & Biological PsychiatryOct 16

The potential role of the gephyrin-CNTNAP4 interface in brain aging: Mechanisms of inhibitory circuit dysfunction and cognitive decline

Figure from Progress in Neuro-psychopharmacology & Biological Psychiatry

ReviewMechanisms

Paper

Thursday, October 15

Journal of Alzheimer's Disease ReportsOct 15

Brain health in older adults: At the crossroads of frailty and resilience

Trajectory of age-dependent cognitive decline.

ReviewMechanisms

Paper

Ageing Research ReviewsOct 15

Turning Back the Ageing Clock? Brain Age in Neuroprotective and Clinical Interventions

ReviewBrain age

Paper

arXivOct 15

Brain activity changes differ from age-group patterns

A longitudinal observational analysis of the Dallas Lifespan Brain Study found substantial differences in early and middle adulthood that diminished later in life.A longitudinal observational analysis of the Dallas Lifespan Brain Study found substantial differences in early and middle adulthood that diminished later in life.

A large brain seen from above has branching connections differing from those in smaller blue and gray brains, with upright faceless people nearby.

Preprint: cohort studyPopulations

Paper

Wednesday, October 14

Alzheimer's & DementiaOct 14

Air pollution linked to inflammation markers, mainly in women

A three-year observational study of 226 middle-aged people at increased Alzheimer’s risk linked traffic pollution to rising markers of brain-support cells and…A three-year observational study of 226 middle-aged people at increased Alzheimer’s risk linked traffic pollution to rising markers of brain-support cells and inflammation.