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Biomarker

4 papers3 findings

MeSH

  • Animals3
  • Model organisms1

Interventions

2

Heterochronic parabiosis

upin mice1

1 study

  1. Heterochronic parabiosis improves transcriptome in mice.

    “heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types”

    Animalsbrain

    Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

    Nature agingMar 9, 2023

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Refeeding

downin mice1−96% abolished

1 study

  1. Refeeding decreases transcriptome in mice (96% abolished).

    “Shifting from long-term DR to RF abolished 96% of the DR-mediated changes in differential gene expression within 2 weeks”

    Animalsliver2 weeksmales

    Beneficial effects of a 6-month dietary restriction are time-dependently abolished within 2 weeks or 6 months of refeeding-genome-wide transcriptome analysis in mouse liver

    Free radical biology & medicineApr 3, 2013

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Associations

1

SNCA

mixedin rats1

1 study

  1. SNCA is associated with transcriptome in rats.

    “revealing that SNCA overexpression leads to age-dependent transcriptomic changes that largely occur region-specific”

    Animalsbrain

    Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model

    AgingOct 20, 2025

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Funding

14 grants since 2016

Japan Society for the Promotion of ScienceJP¥69.2mSwiss National Science FoundationCHF 3.5mDanmarks Frie ForskningsfondDKK 2.9m

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bioRxiv

End-to-end genome map completed for the naked mole-rat

A genome-sequencing study resolved both inherited copies of the naked mole-rat genome, using gene-activity data from 23 tissues to identify its genes.A genome-sequencing study resolved both inherited copies of the naked mole-rat genome, using gene-activity data from 23 tissues to identify its genes.

Preprint: computational studyAI & data
Paper
Journal of the American Heart Association

Genetic analysis links shared DNA signals to artery disease

An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.

Genetic association studyMechanisms
Paper

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