Refeeding

3 papers7 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 2 countries

Funders: Campus France and 7 more

Animals2
Model organisms1

Outcomes

protein synthesis

upin worms1

1 study

Refeeding increases protein synthesis in worms.
“Refeeding restores protein synthesis in an IRE-1 dependent manner”
Model organismsrecovery from adult reproductive diapause
Selective activation of IRE-1 safeguards restoration of translation and organismal rejuvenation from adult reproductive diapause
bioRxiv (Cold Spring Harbor Laboratory)20 Mar 2026Preprint

IRE-1 branch of unfolded protein response of endoplasmic reticulum

upin worms1

1 study

Refeeding activates IRE-1 branch of unfolded protein response of endoplasmic reticulum in worms.
“Refeeding selectively activates the IRE-1 branch of UPR ER”
Model organismsrecovery from adult reproductive diapause
Selective activation of IRE-1 safeguards restoration of translation and organismal rejuvenation from adult reproductive diapause
bioRxiv (Cold Spring Harbor Laboratory)20 Mar 2026Preprint

Aging-like phenotypes

downin worms1

1 study

Refeeding decreases aging-like phenotypes in worms.
“These phenotypes are largely restored within one day of refeeding, suggesting a rejuvenation effect.”
Model organismsadult reproductive diapause induced by starvation at the last larval stageone day
Selective activation of IRE-1 safeguards restoration of translation and organismal rejuvenation from adult reproductive diapause
bioRxiv (Cold Spring Harbor Laboratory)20 Mar 2026Preprint

BDNF

upin mice1

1 study

Refeeding increases BDNF in mice.
“Progressive refeeding restored Bdnf in the DS but not the PFC.”
Animalsin food-restricted AN-like micedorsal striatum
Unraveling the brain expression of bdnf in a mouse model of anorexia nervosa
Translational psychiatry17 Oct 2025