MT1

1. Caloric restriction increases MT1 in silico.

   “CR broadly induced the expression of genes known to inhibit oxidative stress (e.g., Mt1, Mt2), inflammation (e.g., Nfkbia, Timp3) and tumorigenesis (e.g., Txnip, Zbtb16).”

   In silico

   Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

   BMC genomics·7 Dec 2009

More on Caloric restriction

1. MT1 extends lifespan in mice.

   “MTKO mice of both sexes had shorter lifespans than WT mice.”

   Animalsshown by knockout

   Deficiency of metallothionein-1 and -2 genes shortens the lifespan of the 129/Sv mouse strain

   Experimental gerontology·11 Apr 2015

2. MT1 extends lifespan in mice.

   “overexpression of MT-I in SOD1(G93A) mice significantly extended the lifespan”

   Animalsin SOD1(G93A) micespinal cord

   Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1

   Human molecular genetics·24 Oct 2013

3. MT1 extends lifespan in mice.

   “MT is one of just a handful of proteins that, when overexpressed, has been demonstrated to increase mouse lifespan.”

   Reviewoverexpression

   Metallothionein and the biology of aging

   Ageing research reviews·8 Oct 2010

4. MT1 extends lifespan in mice (approximately 4 mo).

   “Metallothionein mice showed a longer life span (by approximately 4 mo) than FVB mice evaluated by the Kaplan-Meier survival curve.”

   Animals

   Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·3 Apr 2006

1. MT1 protects against oxidative stress and ROS signalling in mice.

   “as well as diet-induced oxidative stress damage.”

   Reviewdiet-induced

   Metallothionein and the biology of aging

   Ageing research reviews·8 Oct 2010

2. MT1 decreases oxidative stress and ROS signalling in mice.

   “aging-induced changes in oxidative stress and related protein biomarkers were attenuated by metallothionein”

   Animalsheart

   Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·3 Apr 2006

More on Oxidative stress and ROS signalling

1. MT1 increases cadmium accumulation in mice.

   “overexpression of MT-1 accelerated Cd accumulation in mice”

   AnimalsMT-1 overexpression

   Elevated metallothionein expression in long-lived species mediates the influence of cadmium accumulation on aging

   GeroScience·11 Jun 2021

1. MT1 decreases motor neuron death in mice.

   “markedly attenuated the pathological features of the mice, including the death of motor neurons”

   Animalsin SOD1(G93A) micespinal cord

   Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1

   Human molecular genetics·24 Oct 2013

1. MT1 decreases SOD1 aggregates in mice.

   “decreased level of SOD1 aggregates within the glial cells of the spinal cord”

   Animalsin SOD1(G93A) micespinal cord

   Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1

   Human molecular genetics·24 Oct 2013

More on SOD1 aggregates

1. MT1 decreases copper dyshomeostasis in mice.

   “Genetically induced MT-I normalized copper dyshomeostasis in the spinal cord”

   Animalsin SOD1(G93A) micespinal cord

   Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1

   Human molecular genetics·24 Oct 2013

1. MT1 decreases disease progression in mice.

   “slowed disease progression”

   Animalsin SOD1(G93A) mice

   Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1

   Human molecular genetics·24 Oct 2013

1. MT1 protects against obesity in mice.

   “MT also protects against development of obesity in mice provided a high fat diet”

   Reviewhigh fat diet

   Metallothionein and the biology of aging

   Ageing research reviews·8 Oct 2010

More on Obesity

1. MT1 protects against diastolic dysfunction in mice.

   “aged myocytes displayed prolonged TR(90), reduced tolerance to high stimulus frequency, and slowed intracellular Ca2+ decay, all of which were nullified by metallothionein”

   Animalsaged cardiomyocytesheart

   Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·3 Apr 2006

More on Diastolic dysfunction