STING

Biomarker

2 papers1 finding

Animals2

Associations

Cellular senescence

upin cells1

1 study

Cellular senescence is associated with STING in cells.
“Here, we present a progressive increase in STING in senescent NP cells with the degradation disorder.”
Cellssenescent cells with impaired STING degradationnucleus pulposus cell
Dysfunction of STING Autophagy Degradation in Senescent Nucleus Pulposus Cells Accelerates Intervertebral Disc Degeneration
International journal of biological sciences8 Apr 2024

Latest

189 in 12 months

Nutrients13 h

Dietary Zinc Glycine Supplementation Attenuates Aging-Driven Cochlear Hair Cell Oxidative Injury and Hearing Loss

Experiments in miceHearing loss

Paper

Cytokine & Growth Factor Reviews19 h

Harnessing cGAS-STING in neurodegeneration: From mitochondrial DNA leakage and microglial reactivity to species-specific translational barriers

ReviewcGAS–STING signalling

Paper

Aging CellYesterday

Mitochondrial DNA and age shape retinal changes in mice

Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signalling.Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signalling.

Experiments in male and female mice with differing mtDNA, against mice with C57 mtDNAMitochondrion

Limit: The mtDNA damage result lost significance when a potential outlier was excluded

Paper

Advanced ScienceYesterday

Immune protein has opposing roles in bone as animals age

Animal experiments found that loss of an immune-signalling protein harmed early bone development but protected against age-related bone loss from middle age onward.Animal experiments found that loss of an immune-signalling protein harmed early bone development but protected against age-related bone loss from middle age onward.

Experiments in male mice, against age-matched WT miceImmune response

Limit: Bone-mass differences supporting the age-dependent reversal were not statistically significant

Paper

Advanced ScienceYesterday

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

ReviewcGAS–STING signalling

Paper

Advanced ScienceYesterday

Yoda1-Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Experiments in cellsBones and joints

Paper

Frontiers in Molecular Biosciences14 Oct

Telomeric autophagy in human health, aging, and diseases

ReviewTelomerase and telomere maintenance

Paper

Advanced Science13 Oct

Disc degeneration and abnormal nerve growth fell in animals

In an animal experiment, a dual-action platform injected into spinal discs also reduced heightened sensitivity to pain.In an animal experiment, a dual-action platform injected into spinal discs also reduced heightened sensitivity to pain.

Experiments in animalsIntervertebral disc degeneration

Paper

Research Square10 Oct

Alpha-synuclein pathology alters lipids in mice and human cells

In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent…In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent fasting.

Preprint: experiments in miceMechanisms

Paper

Journal of Cellular Physiology8 Oct

Sestrin1 protects aging livers and aids exercise in mice

In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.

Experiments in miceExercise

Paper

STING

Associations

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