Programming

Papers on Programming

19,933 papers914 new in 30 days

Sunday, November 8

medRxiv

Map links DNA variation to gene activity in aging human brains

The method identified 49,532 distant gene-regulation links supported by shared genetic signals in molecular data from aging human brains.The method identified 49,532 distant gene-regulation links supported by shared genetic signals in molecular data from aging human brains.

A branching neuron is surrounded by smaller glial cells with matching dark nuclear clusters, while a gray cell has only pale strands.
Preprint: genetic association studyAI & data
iScience

Kidney dysfunction promotes wasting and frailty signs in animals

Loss of kidney filtering units under metabolic and cardiovascular stress led to wasting independent of calorie intake, with muscle loss and frailty-like features.Loss of kidney filtering units under metabolic and cardiovascular stress led to wasting independent of calorie intake, with muscle loss and frailty-like features.

Figure from iScience
Animal studyKidney

Saturday, November 7

Biological Psychiatry

Posttraumatic stress disorder linked to older biological age

Greater symptom severity was linked to up to about two years of advanced age on one DNA-based measure among 21,999 US veterans.Greater symptom severity was linked to up to about two years of advanced age on one DNA-based measure among 21,999 US veterans.

Figure from Biological Psychiatry
Cohort · 21,999 peoplePopulations
Academic Radiology

Recovery after stroke clot removal was possible at 80 and older

At 90 days, 14.7% of patients aged 80 and older met a disability-adjusted recovery measure, compared with 18.9% of younger patients.At 90 days, 14.7% of patients aged 80 and older met a disability-adjusted recovery measure, compared with 18.9% of younger patients.

Figure from Academic Radiology
Cohort · 377 peoplePopulations
Physiotherapy Research International

Exercise may ease pain after osteoporosis-related spine fractures

Pain scores fell 1.24 points more with 12 weeks of supervised exercise than with usual activity in a randomized trial of 48 people.Pain scores fell 1.24 points more with 12 weeks of supervised exercise than with usual activity in a randomized trial of 48 people.

Porous, fractured vertebrae appear beside supervised exercise figures, with fewer pain marks around the dark blue-green spine than the gray spine.
Randomized trial · 44 peopleExercise
bioRxiv

Gene activity patterns diverged across the aging mouse brain

A spatial mapping method measured five types of marks on DNA-packaging proteins alongside gene activity across the adult mouse lifespan.A spatial mapping method measured five types of marks on DNA-packaging proteins alongside gene activity across the adult mouse lifespan.

Mouse brain sections show dense outer cortical marks and sparse fiber tract marks in the larger section, beside a mouse and scattered branching neurons.
Preprint: mouse studyAI & data
Aging Cell

Protein helped drive senescence in lab-grown human eye cells

Experiments implicated a gene-regulating protein in senescence, a state in which cells stop dividing, in human retinal cells grown in the lab.Experiments implicated a gene-regulating protein in senescence, a state in which cells stop dividing, in human retinal cells grown in the lab.

Figure from Aging Cell
Human cell studyCellular senescence