Physiotherapy Research International

Exercise may ease pain after osteoporosis-related spine fractures

Pain scores fell 1.24 points more with 12 weeks of supervised exercise than with usual activity in a randomized trial of 48 people.

Paper by Yasemin Salkın, Zerrin Pelin, Yavuz Yakut, Pinar Muge Sarikaya · Department of Health Care Services Vocational School of Health Services Mersin University Mersin Turkiye
Studied:
Randomized trial in 44 people with osteoporosis-related spine fractures, 12 weeks (Registered NCT05521724)
What changed:
Pain scores fell 1.24 points more with supervised exercise than with usual activity
The catch:
Knowing group assignments could have influenced participants' pain ratings
In the record:
The 3,788th paper on exercise with results in people; 9,704 on record in all. Its result on quality of life agrees with 207 of 235 other findings on record; 1 points the other way and 27 found no change.
Why it’s aging research:
It studies an intervention with evidence of extending healthy life.

Editor of record: Boris Djordjevic · AgingResearch.News

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Forty-eight people with osteoporosis-related spine fractures entered a single-center randomized trial comparing supervised exercise with usual activity. Twenty-four were assigned to each group, and 44 completed the study. The exercise group received individually supervised, 40-minute sessions twice weekly for 12 weeks, focusing on back and leg strengthening, posture and balance.

Exercise appeared to provide greater benefits for pain and physical function. Pain scores fell 1.24 points more than in controls, and six-minute walking distance improved by 38.94 meters more. Questionnaire scores also favored exercise for depression, disability, fear of movement and quality of life. The groups did not differ significantly in sleep quality or daytime sleepiness.

Why it matters

Osteoporosis-related spine fractures can limit physical function and quality of life as people age. The authors suggest incorporating structured exercise into rehabilitation plans for people with these fractures.

Caveats

Participants and researchers knew the group assignments, which could have influenced questionnaire responses. The trial involved one center, and the abstract did not report adverse events.

Where the evidence stands

Exercise

Worms or flies, mice and humans: replicated by independent labs. Cells: a single group.
  • 1,395 independent labs in 88 countries
  • 780 findings against
  • Funders: National Institutes of Health and others
  • 370 of 7,761 findings with company ties

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Exercise is part of Bryan Johnson's Blueprint

The paper

The Effect of Exercise Training on Individuals With Osteoporotic Vertebral Fracture: A Randomized Controlled Trial

Department of Health Care Services Vocational School of Health Services Mersin University Mersin Turkiye; Department of Physical Medicine and Rehabilitation Faculty of Medicine Mersin University Mersin Turkiye

Physiotherapy Research International, Nov 7, 2026

doi.org/10.1002/pri.70377