Open-angle glaucoma
Disease4 papers4 findings
- Human trial1
- Humans3
Associations
4Diabetes
upin humans1
1 study
Diabetes
upin humans1
Diabetes raises the risk of open-angle glaucoma in humans.
Humanssimilarly in both sexes
Age, sex, and hormone therapy are associated with open-angle glaucoma: a case-only analysis in U.S. veterans · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 11 Sep 2026
Hormone therapy
downin humans1Low certainty
1 study
Hormone therapy
downin humans1Low certainty
Hormone therapy lowers the risk of open-angle glaucoma in humans.
Humansin females, greatest effect in those <45 yearsfemales
Age, sex, and hormone therapy are associated with open-angle glaucoma: a case-only analysis in U.S. veterans · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 11 Sep 2026
Open-angle glaucoma genetic risk score
upin humans1OR 3.83
1 study
Open-angle glaucoma genetic risk score
upin humans1OR 3.83
Open-angle glaucoma genetic risk score raises the risk of open-angle glaucoma in humans (OR 3.83, 95% CI 1.89–7.78).
Humanshigh myopes with MMD
A Comprehensive Assessment of the Shared Genetic Architecture between Myopia and Open-Angle Glaucoma · Ophthalmology science · 22 Jul 2026
Myopia genetic risk score
upin humans1OR 1.18
1 study
Myopia genetic risk score
upin humans1OR 1.18
Myopia genetic risk score raises the risk of open-angle glaucoma in humans (OR 1.18, 95% CI 1.09–1.28).
Humansn = 34,825
A Comprehensive Assessment of the Shared Genetic Architecture between Myopia and Open-Angle Glaucoma · Ophthalmology science · 22 Jul 2026
Trial sponsors
Company1 trialPhase 453 people
Company2 trialsPhase 32,298 people
Company1 trialPhase 118 people
Glostrup University Hospital, Copenhagen
1 trialPhase 4126 people
Federal University of São Paulo
1 trialPhase 435 people
Funding
National Eye InstituteUS$1.4mVeterans Affairs3 grants since 2022
Latest
7Statin use is associated with lower risk of open-angle glaucoma incidence and treatment escalation
Macrophage-derived VEGFA maintains eye outflow in mice
Deleting Vegfa in CX3CR1-positive macrophages raised intraocular pressure and reduced aqueous humor outflow facility in nine-month-old mice.Deleting Vegfa in CX3CR1-positive macrophages raised intraocular pressure and reduced aqueous humor outflow facility in nine-month-old mice.