An experiment comparing young and older mice found an immune-cell-like profile in artery muscle cells only when aging and high cholesterol occurred together.An experiment comparing young and older mice found an immune-cell-like profile in artery muscle cells only when aging and high cholesterol occurred together.
Who was studiedYoung and aged mice, against young high-cholesterol and aged normal-cholesterol mice
What changedMacrophage-like artery muscle cell profiles appeared only in aged high-cholesterol mice, not young high-cholesterol or aged normal-cholesterol mice
The catchDiet and genetic background differed between groups, complicating attribution to aging and cholesterol
Adults with both kinds of disorders had a stroke hazard ratio—a measure of relative risk—of 1.33 compared with those with neither.Adults with both kinds of disorders had a stroke hazard ratio—a measure of relative risk—of 1.33 compared with those with neither.
For low calcium, adjusted hazard ratios—measures of relative event rates—rose from 1.27 with one abnormal reading to 1.84 with at least three.For low calcium, adjusted hazard ratios—measures of relative event rates—rose from 1.27 with one abnormal reading to 1.84 with at least three.
Laboratory experiments traced how stem-cell-derived blood vessel cells used nutrients to support DNA building blocks and persistent responses to DNA damage in progeria.Laboratory experiments traced how stem-cell-derived blood vessel cells used nutrients to support DNA building blocks and persistent responses to DNA damage in progeria.
During follow-up from 2018 through 2023, dementia occurred in 6.8% of adults with both disorder types versus 2.3% with neither.During follow-up from 2018 through 2023, dementia occurred in 6.8% of adults with both disorder types versus 2.3% with neither.
An observational study of 20,461 participants followed for a median 8.6 years linked more daily steps to lower high blood pressure, obesity and type 2 diabetes risk.An observational study of 20,461 participants followed for a median 8.6 years linked more daily steps to lower high blood pressure, obesity and type 2 diabetes risk.
Over a median 15.3 years, heart failure occurred in 20.3% of adults with clustered diagnoses, compared with 6.2% whose obesity was diagnosed first.Over a median 15.3 years, heart failure occurred in 20.3% of adults with clustered diagnoses, compared with 6.2% whose obesity was diagnosed first.
The definitions disagreed for 17.5% of All of Us participants and 29.1% of UK Biobank participants, with different links to later disease.The definitions disagreed for 17.5% of All of Us participants and 29.1% of UK Biobank participants, with different links to later disease.
Coronary artery disease odds were about 1.07 times as high per doubling of genetically estimated lipoprotein(a), a fat-carrying blood particle.Coronary artery disease odds were about 1.07 times as high per doubling of genetically estimated lipoprotein(a), a fat-carrying blood particle.
Diet-quality scores rose 3.15 points from baseline over eight months across two meal programs for adults with type 2 diabetes and high blood pressure.Diet-quality scores rose 3.15 points from baseline over eight months across two meal programs for adults with type 2 diabetes and high blood pressure.
An observational analysis of 152,617 women aged 40–65 linked earlier menopausal stages to greater benefits from one class of diabetes and weight-loss drugs.An observational analysis of 152,617 women aged 40–65 linked earlier menopausal stages to greater benefits from one class of diabetes and weight-loss drugs.
Among patients rated low risk, heart attacks and strokes occurred at 8.0-fold and 6.5-fold the rates predicted by two standard calculators.Among patients rated low risk, heart attacks and strokes occurred at 8.0-fold and 6.5-fold the rates predicted by two standard calculators.
Each extra hour of deep sleep was linked to 13.5% lower relative risk; each extra hour of rapid eye movement sleep to 11.3% lower risk.Each extra hour of deep sleep was linked to 13.5% lower relative risk; each extra hour of rapid eye movement sleep to 11.3% lower risk.
A genetic analysis identified 112 DNA regions linked to both coronary artery disease and traits related to thinking or education.A genetic analysis identified 112 DNA regions linked to both coronary artery disease and traits related to thinking or education.
Five-year mortality was similar after circulatory-death versus brain-death donation, with a hazard ratio of 0.99 comparing death rates over time.Five-year mortality was similar after circulatory-death versus brain-death donation, with a hazard ratio of 0.99 comparing death rates over time.
More than 1,200 blood proteins were linked to future heart failure about 18 years before diagnosis, rising to about 3,600 closer to diagnosis.More than 1,200 blood proteins were linked to future heart failure about 18 years before diagnosis, rising to about 3,600 closer to diagnosis.
Mice engineered to increase glucose breakdown in blood vessel–lining cells showed poorer blood-flow recovery and lower capillary density after hindlimb blood supply was…Mice engineered to increase glucose breakdown in blood vessel–lining cells showed poorer blood-flow recovery and lower capillary density after hindlimb blood supply was restricted.
Newborn mice missing one pathway protein had hearts about 30% smaller than normal mice, with fewer heart muscle cells.Newborn mice missing one pathway protein had hearts about 30% smaller than normal mice, with fewer heart muscle cells.
