Hyperkalemia
Disease1 paper1 findingMeSH D006947
- Animals1
Interventions
1Amiloride
upin mice1Very low certainty
1 study
Amiloride
upin mice1Very low certainty
Amiloride induces hyperkalemia in mice.
Animalsin KLhet mice
Klotho deficiency disrupts potassium balance in mice · Acta physiologica (Oxford, England) · 5 Oct 2026
Latest
1Acta PhysiologicaAnimals
Klotho deficiency disrupts potassium balance in mice
In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation…In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation reversed.