Major bleeding

1. Klemera-Doubal biological age predicts major bleeding in humans (Adjusted HR 2.12 (95% CI 1.60–2.83)).

   “composite outcomes, death, major bleeding, SSE, and heart failure were 2.11 (1.82-2.45), 2.53 (2.06-3.11), 2.12 (1.60-2.83), 1.96 (1.37-2.78), and 1.83 (1.42-2.38), respectively”

   HumansPatients with atrial fibrillation; quartile 4 KDM biological age; adjusted analysisMedian 35.9 monthsBoth; 1424 (41.8%) femalesn = 3,405

   Impact of biological age versus chronological age on clinical outcomes in patients with atrial fibrillation: insights from the COOL-AF registry

   Journal of thrombosis and thrombolysis·12 Jan 2026

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1. History of falls are associated with major bleeding in humans.

   “had a higher risk of major adverse events, including all-cause mortality, thromboembolism, and major bleeding.”

   Humanspatients with atrial fibrillationn = 20,875

   History of falls in patients with atrial fibrillation and risk of major outcomes: analysis from the Prospective GLORIA-AF Registry

   GeroScience·28 Aug 2025

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