Mitophagy

Papers on mitophagy

1,317 papers56 new in 30 days

Monday, November 2

EMBO Reports

Amyloid linked to reduced mitochondrial cleanup in neurons

Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing…Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing structures.

Experiments in miceInterventions
Nature Communications

Worms lacking a regulatory protein lived longer on certain diets

Worm experiments traced the lifespan benefit to vitamin B12-dependent enzymes and a process that removes mitochondria, the cell’s energy-producing structures.Worm experiments traced the lifespan benefit to vitamin B12-dependent enzymes and a process that removes mitochondria, the cell’s energy-producing structures.

Experiments in wormsMechanisms

Sunday, November 1

Saturday, October 31

Biochemical Pharmacology

Raising a protein eased signs of osteoporosis in mice

Experiments in mice whose ovaries had been removed found that increasing a mitochondrial protein eased signs of osteoporosis.Experiments in mice whose ovaries had been removed found that increasing a mitochondrial protein eased signs of osteoporosis.

Friday, October 30

Thursday, October 29

Frontiers in Aging Neuroscience

Human neurons made from older donors show cleanup defects

Experiments in neurons made from healthy donors aged 11 to 91 found impaired removal of damaged mitochondria, the cells’ energy-producing structures.Experiments in neurons made from healthy donors aged 11 to 91 found impaired removal of damaged mitochondria, the cells’ energy-producing structures.

Human cell studyMechanisms
Materials Today Bio

Injectable gel improved bone repair in rats

An animal experiment found improved bone volume, mineral density and blood vessel formation in rat thighbone defects after delivery of engineered cell-released particles.An animal experiment found improved bone volume, mineral density and blood vessel formation in rat thighbone defects after delivery of engineered cell-released particles.

Wednesday, October 28

Advanced Science

Protein helps bone marrow stem cells develop into bone cells

Experiments in bone marrow stem cells linked the protein to mitochondrial maintenance and signals that support blood vessel formation.Experiments in bone marrow stem cells linked the protein to mitochondrial maintenance and signals that support blood vessel formation.

Animal cell studyBones and joints

Tuesday, October 27

Cell Reports

Cellular energy defects worsened heart disease in Fabry mice

Experiments in a humanized mouse model found worsening energy production and waste disposal with age; L-arginine prevented heart abnormalities.Experiments in a humanized mouse model found worsening energy production and waste disposal with age; L-arginine prevented heart abnormalities.

Mouse studyInterventions

Monday, October 26

Advanced Science

In cells, senescent fat stem cells transfer damaged mitochondria

Cell experiments showed that vesicles from senescent fat stem cells carried damaged mitochondria, disrupting mitochondrial balance and activating inflammatory signaling…Cell experiments showed that vesicles from senescent fat stem cells carried damaged mitochondria, disrupting mitochondrial balance and activating inflammatory signaling in spinal disc cells.

Senescent ADSC‐derived MVs lose the protective effects of normal ADSC‐derived MVs and aggravate mitochondrial inflammatory injury in NPCs.
Human cell studyCellular senescence

Sunday, October 25

Friday, October 23

Theranostics

Removing a gene reduced age-related bone loss in mice

In experiments with 12 mice per group, deleting the gene in bone-building cells reduced bone loss after 12 weeks of chemically induced aging.In experiments with 12 mice per group, deleting the gene in bone-building cells reduced bone loss after 12 weeks of chemically induced aging.

Osteoblast-specific knockdown of ARG2 alleviates age-related osteoporosis.
Mouse studyBones and joints