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Cepharanthine

Cepharanthine has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Nov 1, 2026: “Cepharanthine clears senescent cells in naturally aged mice”.

Intervention

1 paper studies it5 findingsUpdated

PubChemChEBI

1 new paper in 30 daysSee all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Guangzhou Municipal Science and Technology Project and 3 more
  • Animals1

What did studies of Cepharanthine find?

3

Studies of Cepharanthine measured 3 outcomes; the most studied are lifespan (1 study), mitochondrial intrinsic apoptosis (1) and senescent cells (1).

Lifespan

upin mice1upin worms1upin zebrafish1

1 study

  1. Cepharanthine extends lifespan in mice (naturally aged mice and HGPS mice).

    “In zebrafish, C. elegans, naturally aged mice and HGPS mice, CEP clears senescent cells, reduces SASP levels, improves organ function and prolongs lifespan.”

    Animalsnaturally aged mice and HGPS mice

    Cepharanthine clears senescent cells in naturally aged mice

    Phytomedicine : international journal of phytotherapy and phytopharmacology

  2. Cepharanthine extends lifespan in worms.

    “In zebrafish, C. elegans, naturally aged mice and HGPS mice, CEP clears senescent cells, reduces SASP levels, improves organ function and prolongs lifespan.”

    Model organisms

    Cepharanthine clears senescent cells in naturally aged mice

    Phytomedicine : international journal of phytotherapy and phytopharmacology

  3. Cepharanthine extends lifespan in zebrafish.

    “In zebrafish, C. elegans, naturally aged mice and HGPS mice, CEP clears senescent cells, reduces SASP levels, improves organ function and prolongs lifespan.”

    Animals

    Cepharanthine clears senescent cells in naturally aged mice

    Phytomedicine : international journal of phytotherapy and phytopharmacology

mitochondrial intrinsic apoptosis

upin cells1

1 study

  1. Cepharanthine induces mitochondrial intrinsic apoptosis in cells (senescent cells).

    “CEP is a novel natural senolytic that induces mitochondrial intrinsic apoptosis”

    Cellssenescent cells

    Cepharanthine clears senescent cells in naturally aged mice

    Phytomedicine : international journal of phytotherapy and phytopharmacology

Senescent cells

downin cells1

1 study

  1. Cepharanthine decreases senescent cells in cells.

    “CEP selectively eliminates senescent cells”

    Cells

    Cepharanthine clears senescent cells in naturally aged mice

    Phytomedicine : international journal of phytotherapy and phytopharmacology

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 01 paper in 12 months
Phytomedicine

Cepharanthine clears senescent cells in naturally aged mice

Experiments in naturally aged mice found that the compound also improved organ function and prolonged lifespan.Experiments in naturally aged mice found that the compound also improved organ function and prolonged lifespan.

Mouse studyInterventions
Paper

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